I am not a statistician - but 14 total instances in all studies? This seems like a study group too small to analyze with meaningful significance - the expected

I am not a statistician - but 14 total instances in all studies? This seems like a study group too small to analyze with meaningful significance - the expected variance is very large with such a small sample. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892150/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892150/ And not to downplay at all - but 14 cases being the total possible over a ~30 year time-frame seems like a mute issue compared to any other life threatening issues.