4 ms·

Could that tech of re-engineering T-cells be a step to cure psoriasis? AFAIK psoriasis is caused by T-cells erroneously targeted to kill epidermis.

by Eli_P 8y ago

refurb 8y ago
With the current CAR-T technology, you’re “turning on” the T-cell so it attacks certain cell types. You only need a few of those cells as they can multiply within the body. What you’re talking about is the opposite, turning the T cell “off”. You’d also need to do that to every T cell or alternatively, destroy every T cell and restart with a batch of new cells. Very different problems.
- WalterSear 8y ago
  Or program the T-cells to attack mesenchymal cells that are producing the defective ones. I'd wager that the process would still be much more difficult than targeting cancerous cells, and certainly be very complicated. But, there's hope for other diseases, though the article is focused on cancer: > Not only can this technology help revolutionize TCR-T cell therapies for cancer, but it will also be a powerful tool for discovering other immunological agents, including antibodies and CAR-T cells, and for elucidating new immunology and cancer biology at a depth not possible before.
mrfusion 8y ago
I have an idea for curing psoriasis. It sounds really ridiculous but seeing eating local honey cured my pollen allergies I think it could be worth a try.
- JPLeRouzic 8y ago
  I am curious about your idea, do you mean that it would be enough to eat honey to cure psoriasis, or is it something else? Thanks!
  - mrfusion 8y ago
    I’m proposing eating that which your allergies are attacking. Your skin. I guess you’d need to design some kind of exfoliator to get enough skin. I told you it sounds ridiculous.
    - rich_ard 8y ago
      And for good reason
    - JPLeRouzic 8y ago
      It may sound ridiculous but it is an interesting idea. Normally an adaptive immune reaction has two phases, one where T-cells are aggressively deployed and another where it slows down (resolution phase). Many chronic diseases involve some kind of "immune vicious circle" with no resolution phase. T-cells are "educated" mainly in the thymus, if it was possible to alter the education mechanism, we could better manage auto-immune diseases. At least your suggestion is yummy food for thought, thanks!

Could that tech of re-engineering T-cells be a step to cure psoriasis? AFAIK psoriasis is caused by T-cells erroneously targeted to kill epidermis.

by Eli_P 8y ago

Could that tech of re-engineering T-cells be a step to cure psoriasis? AFAIK psoriasis is caused by T-cells erroneously targeted to kill epidermis.

refurb 8y ago

With the current CAR-T technology, you’re “turning on” the T-cell so it attacks certain cell types. You only need a few of those cells as they can multiply within the body. What you’re talking about is the opposite, turning the T cell “off”. You’d also need to do that to every T cell or alternatively, destroy every T cell and restart with a batch of new cells. Very different problems.

WalterSear 8y ago
Or program the T-cells to attack mesenchymal cells that are producing the defective ones. I'd wager that the process would still be much more difficult than targeting cancerous cells, and certainly be very complicated. But, there's hope for other diseases, though the article is focused on cancer: > Not only can this technology help revolutionize TCR-T cell therapies for cancer, but it will also be a powerful tool for discovering other immunological agents, including antibodies and CAR-T cells, and for elucidating new immunology and cancer biology at a depth not possible before.

mrfusion 8y ago

I have an idea for curing psoriasis. It sounds really ridiculous but seeing eating local honey cured my pollen allergies I think it could be worth a try.

JPLeRouzic 8y ago
I am curious about your idea, do you mean that it would be enough to eat honey to cure psoriasis, or is it something else? Thanks!
- mrfusion 8y ago
  I’m proposing eating that which your allergies are attacking. Your skin. I guess you’d need to design some kind of exfoliator to get enough skin. I told you it sounds ridiculous.
  - rich_ard 8y ago
    And for good reason
  - JPLeRouzic 8y ago
    It may sound ridiculous but it is an interesting idea. Normally an adaptive immune reaction has two phases, one where T-cells are aggressively deployed and another where it slows down (resolution phase). Many chronic diseases involve some kind of "immune vicious circle" with no resolution phase. T-cells are "educated" mainly in the thymus, if it was possible to alter the education mechanism, we could better manage auto-immune diseases. At least your suggestion is yummy food for thought, thanks!