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Sorry, I don't understand. Elsewhere you said > no at the “effective” dose it likely won’t matter the problem is that effective dose is irrelevant in this cas

Sorry, I don't understand. Elsewhere you said > no at the “effective” dose it likely won’t matter the problem is that effective dose is irrelevant in this case because we are talking about substance abuse. Do you disagree with either of these? 1. In popular news coverage, or doctors talking with lay patients, the term "power" or "strength" of an opioid is shorthand for it's potency on normal (non-addicted) patients. That is, it is inversely related to the number of milligrams that must be administered to get effective pain relief for some fixed reference injury. 2. The potency of a drug is only weakly correlated with its potential for addiction. There are several opioids that are less potent than average but have a higher propensity for addiction than average, and vice versa.

dogma1138 8y ago
Ok "affinity" it's how strongly it would bind to a receptor. Then there is agonism or antagonism which can be partial or full. Full agonism is the "strongest" activation that doesn't have anything to do with affinity because it just means it fully activates the receptor, the affinity is how likely it will be bound to the receptors. For opioids that are full agonists potency and affinity can be used essentially interchangeably these are all primary pain relief opioids and fully bind to the receptors in the same manner essentially, opioids which are mixed agonists or even antagonists such as those used to treat addiction or withdrawal can have very high affinity but low potency because while they bind to the receptor very strongly they don't fully activate it or even deactivate it but as their affinity is high they can beat other opioids to the binding and block the receptors. As this drug is a replacement for fentanyl it's a full agonist opioid which means that if it's more potent it has to have a lower Ki value which means higher affinity at a matching ratio.

dogma1138 8y ago

Ok "affinity" it's how strongly it would bind to a receptor. Then there is agonism or antagonism which can be partial or full. Full agonism is the "strongest" activation that doesn't have anything to do with affinity because it just means it fully activates the receptor, the affinity is how likely it will be bound to the receptors. For opioids that are full agonists potency and affinity can be used essentially interchangeably these are all primary pain relief opioids and fully bind to the receptors in the same manner essentially, opioids which are mixed agonists or even antagonists such as those used to treat addiction or withdrawal can have very high affinity but low potency because while they bind to the receptor very strongly they don't fully activate it or even deactivate it but as their affinity is high they can beat other opioids to the binding and block the receptors. As this drug is a replacement for fentanyl it's a full agonist opioid which means that if it's more potent it has to have a lower Ki value which means higher affinity at a matching ratio.