3 ms·
No way that’s true. Buprenorphine has a much higher binding affinity than all the worst opiates yet you don’t see people trying to do that over heroin and all t
by skellera 8y ago
No way that’s true. Buprenorphine has a much higher binding affinity than all the worst opiates yet you don’t see people trying to do that over heroin and all the others.
The strengths you’re speaking of are potency. And even then, most addicts I know would rather have an unlimited supply of oxymorphone than fentanyl or any of the others. At a certain point, cost outweighs all of that.
There’s so much misinformation out there about these drugs.
- pimeys 8y agoYou should watch a movie called Reindeerspotting about junkies in Lapland doing buprenorphine. It is quite addictive.
- dogma1138 8y agoBuprenorphine is a partial agonist of the Mu receptor (the one which causes the most physical dependency) and is antagonist for the rest, it’s also has a very high affinity which displaces other opioids which is why it’s used in addiction treatment. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581407/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581407/ Yes is more to this than just affinity the type and level of the binding to each receptor is also important but on the grand scheme of things in this context it’s not because all the opioids which are primarily used for pain relief are full Mu receptor agonists which is when the simple affinity strength estimate is pretty much sufficient to estimate potency and potential harm. Also last time I checked the potency is derived directly from the Ki value of the Mu receptor which represents the affinity (regardless of agonism) of the opioid, so these are essentially interchangeable.