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I don't think that article answers my question. This seems to be the entire contents that might directly address the issue: > The new, deadlier drugs are alte

I don't think that article answers my question. This seems to be the entire contents that might directly address the issue: > The new, deadlier drugs are altered opioids that bind in more powerful ways to the brain’s receptors and get to the brain more quickly. The combination of factors can make them thousands of times more deadly. > All opioids connect to particular brain and nervous system receptors that exist for the body’s natural painkiller, endorphins... That is the only mention of the word "bind" and the article doesn't contain the word "affinity". It doesn't discuss the relationship between effective-dose-size and potential for addiction, except in cases where it seems to go in the opposite direction of what you suggested: > Methadone is about three times stronger than morphine, but it does not produce a strong euphoric effect. It also lasts much longer and can address physical dependence on other opioids, making it the most common choice for treating opioid addiction.

dogma1138 8y ago
It did when you only had “do you have a cite for this” check my edit look at opioid agonism studies especially around addiction treatments where weak/partial agonists opioids are used to ease widthrawal symptoms without prolonging addiction. Which of receptors the opioids can bind to and at what level also has impact on their addiction as many of these receptors regulate different functions iirc the ones that cause the most physical dependence are the strong Mu receptor agonists.
- jessriedel 8y ago
  > It did when you only had “do you have a cite for this” check my edit Oh gotcha, sorry about that. I edited my top-level comment fast, so I just assumed you hadn't had time to read the initial version. > opioid agonism studies especially around addiction treatments where weak/partial agonists opioids are used to ease widthrawal symptoms without prolonging addiction. OK, I spend 10 minutes Googling. I found a few authoritative lists of addictiveness that didn't seem to correlate with effective dose (which I am pretty confident is the measure of "power" being discussed in the article). And I couldn't find anything that asserted a reasonably robust correlation between effective dose size and addictiveness, whether mediated by agonism strength or otherwise. But I understand if you don't want to spend a bunch of time on this. Thanks.
  - dogma1138 8y ago
    Now I understand what are you looking for no at the “effective” dose it likely won’t matter the problem is that effective dose is irrelevant in this case because we are talking about substance abuse. All full Mu receptors agonists can cause severe physical dependency, the stronger the affinity the more they also can push out other opioids and natural occurring ones and as over time the opioids can actually affect the “shape” of the receptor this is essentially what causes the addiction since what your body produces like endorphine is no longer good enough for you. So if this will be prescribed like fentanyl and other opioids this will be a problem the opioid epidemic didn’t happen because opioids were tightly prescribed and administered in controlled conditions it happened because you sprained your back and instead of some physiotherapy and a sauna you’ve been given a bottle of pills to chew on like candy.
    - jessriedel 8y ago
      Cool, thanks!

dogma1138 8y ago

It did when you only had “do you have a cite for this” check my edit look at opioid agonism studies especially around addiction treatments where weak/partial agonists opioids are used to ease widthrawal symptoms without prolonging addiction. Which of receptors the opioids can bind to and at what level also has impact on their addiction as many of these receptors regulate different functions iirc the ones that cause the most physical dependence are the strong Mu receptor agonists.

jessriedel 8y ago
> It did when you only had “do you have a cite for this” check my edit Oh gotcha, sorry about that. I edited my top-level comment fast, so I just assumed you hadn't had time to read the initial version. > opioid agonism studies especially around addiction treatments where weak/partial agonists opioids are used to ease widthrawal symptoms without prolonging addiction. OK, I spend 10 minutes Googling. I found a few authoritative lists of addictiveness that didn't seem to correlate with effective dose (which I am pretty confident is the measure of "power" being discussed in the article). And I couldn't find anything that asserted a reasonably robust correlation between effective dose size and addictiveness, whether mediated by agonism strength or otherwise. But I understand if you don't want to spend a bunch of time on this. Thanks.
- dogma1138 8y ago
  Now I understand what are you looking for no at the “effective” dose it likely won’t matter the problem is that effective dose is irrelevant in this case because we are talking about substance abuse. All full Mu receptors agonists can cause severe physical dependency, the stronger the affinity the more they also can push out other opioids and natural occurring ones and as over time the opioids can actually affect the “shape” of the receptor this is essentially what causes the addiction since what your body produces like endorphine is no longer good enough for you. So if this will be prescribed like fentanyl and other opioids this will be a problem the opioid epidemic didn’t happen because opioids were tightly prescribed and administered in controlled conditions it happened because you sprained your back and instead of some physiotherapy and a sauna you’ve been given a bottle of pills to chew on like candy.
  - jessriedel 8y ago
    Cool, thanks!