3 ms·

If you are interested in learning more the general name for this drug (outside of the US) is ARX-04. The maker has some data that compares it to Fentanyl [1].

If you are interested in learning more the general name for this drug (outside of the US) is ARX-04. The maker has some data that compares it to Fentanyl [1]. Their numbering states that is closer to 100x, and crosses the blood brain barrier in around 6 minutes. [1] http://www.acelrx.com/technology/publications/arx-04/MHSRS%20ProjTeamPresentation%202016%20FINAL%2008_10_16%20MRC-0076.pdf http://www.acelrx.com/technology/publications/arx-04/MHSRS%2... here

trhway 8y ago
another 100x fentanyl - carfentanyl as gas/aerosol was used by the SWAT team in the 2002 Moscow hostage crisis. 100+ people died from it: https://en.wikipedia.org/wiki/Moscow_hostage_crisis_chemical_agent#Opioid_version https://en.wikipedia.org/wiki/Moscow_hostage_crisis_chemical...
vilhelm_s 8y ago
Interesting. I'm a bit confused about slide 6, which says that it has a theraputic index which is 100 times better than fentanyl. It cites the reference [1], which indeed has those numbers in it, but the full table there is: ED50 LD50 Theaputic Index Fentanyl 0.01 3.1 277 Sufentanil 0.007 18 26716 The therapeutic index is the ratio of LD50:ED50. This clearly makes no sense, someone must have moved a decimal point, and got a number which is wrong by a factor 10. EDIT: Ok, it seems that it is indeed an error in the cited paper, but the typo is for the ED50 number. In the original source[2] it's given as 0.00071, which agrees with the "10 times stronger than fentanyl" claim in the original article, and gives the correct theraputic index. [1] https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1681.1995.tb01945.x https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1681.... [2] https://twitter.com/davidjuurlink/status/859227636400349184?lang=en https://twitter.com/davidjuurlink/status/859227636400349184?...

trhway 8y ago

another 100x fentanyl - carfentanyl as gas/aerosol was used by the SWAT team in the 2002 Moscow hostage crisis. 100+ people died from it: https://en.wikipedia.org/wiki/Moscow_hostage_crisis_chemical_agent#Opioid_version https://en.wikipedia.org/wiki/Moscow_hostage_crisis_chemical...

vilhelm_s 8y ago

Interesting. I'm a bit confused about slide 6, which says that it has a theraputic index which is 100 times better than fentanyl. It cites the reference [1], which indeed has those numbers in it, but the full table there is: ED50 LD50 Theaputic Index Fentanyl 0.01 3.1 277 Sufentanil 0.007 18 26716 The therapeutic index is the ratio of LD50:ED50. This clearly makes no sense, someone must have moved a decimal point, and got a number which is wrong by a factor 10. EDIT: Ok, it seems that it is indeed an error in the cited paper, but the typo is for the ED50 number. In the original source[2] it's given as 0.00071, which agrees with the "10 times stronger than fentanyl" claim in the original article, and gives the correct theraputic index. [1] https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1681.1995.tb01945.x https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1681.... [2] https://twitter.com/davidjuurlink/status/859227636400349184?lang=en https://twitter.com/davidjuurlink/status/859227636400349184?...