3 ms·
>"Were there any surprise findings? NTP found longer lifespans among the exposed male rats. This may be explained by an observed decrease in chronic kidney prob
by tynpeddler 8y ago
>"Were there any surprise findings? NTP found longer lifespans among the exposed male rats. This may be explained by an observed decrease in chronic kidney problems that are often the cause of death in older rats"
The increased lifespan could be at least partially responsible for the increased cancer rates. All populations that see an increase in lifespan see an increase in cancer rates. Cancer seems to be the default prize for living a long life.
Also, the caption on slide 20 for their BioEM2016 Meeting, Ghent, Belgium, June 8, 2016 presentation surprised me a litte. It states that the historical control incidence of malignant gliomas is in the range of 0-8%. This study saw a rate of 0% for its controls. That's not unreasonable but it is interesting. It's also odd that they did not see an indication of a dose response curve for GSM modulation, though admittedly the number of samples is low.
I don't doubt the statistical significance of the evidence presented, but data patterns suggest that it's at least a little possible that there's an issue with their protocol.
- meowface 8y ago>The increased lifespan could be at least partially responsible for the increased cancer rates. All populations that see an increase in lifespan see an increase in cancer rates. Of course, but wouldn't this be so obvious that the researchers would undoubtedly have accounted for that as a confounding variable? At least I hope so.
- TeMPOraL 8y ago> Of course, but wouldn't this be so obvious that the researchers would undoubtedly have accounted for that as a confounding variable? At least I hope so. Woudln't count on that these days, in general. If something is accounted for, it's usually stated in the paper.
- tynpeddler 8y agoThat's what I thought, but I wasn't able to find where they addressed this issue. If you can point me to the control for lifespan, I'd appreciate it.