If you're listening to uncompressed (losslessly compressed) audio, you're mostly fine with Bluetooth. But if your source is already lossily compressed, they you

If you're listening to uncompressed (losslessly compressed) audio, you're mostly fine with Bluetooth. But if your source is already lossily compressed, they you're multiplying the artifacts of MP3 or AAC by the artifacts of aptX or SBC, and that becomes very audible if you know what to listen for.