5 ms·

As I understand it THC aggravates symptoms in people predisposed to psychosis. CBD is antipsychotic and can have a balancing effect but unfortunately growers ha

by galvin 8y ago

As I understand it THC aggravates symptoms in people predisposed to psychosis. CBD is antipsychotic and can have a balancing effect but unfortunately growers have been selectively breeding and optimizing for high THC at the expense of CBD for decades. The result is that cannabis is more "incompatible" with certain people than it used to be.

the-pigeon 8y ago
Which is one of the big problems with cannabis studies. THC is known as the "active" ingredient in cannabis. However we know it's definitely not the only one. There are 113 identified cannabinoids. Most are believed to have some effect. And there's terpenes that are believed to have effects as well. So the problem is that ever single bit of cannabis has different ratios of these chemicals. Even two plants with the exact same genetics grown in same conditions can have widely ranging ratios. Which potentially means widely ranging effects. The good thing is with legalization moving along we should see a lot more high quality studies that can help us figure this out. https://en.wikipedia.org/wiki/Cannabinoid https://en.wikipedia.org/wiki/Cannabinoid https://www.leafly.com/news/cannabis-101/terpenes-the-flavors-of-cannabis-aromatherapy https://www.leafly.com/news/cannabis-101/terpenes-the-flavor... http://www.ncsm.nl/english/what-is-medicinal-cannabis/active-ingredients#Terpenes http://www.ncsm.nl/english/what-is-medicinal-cannabis/active...
- weberc2 8y ago
  > The good thing is with legalization moving along we should see a lot more high quality studies that can help us figure this out. This is tangential, but it seems odd to me that many of the same people who are opposed to GMOs on the grounds that “science may have missed something” are okay with legalizing pot until science clearly demonstrates harm. Note that I’m not directing that at you (I don’t think you said anything like what I’m describing), but your quip made me think of it. I’m only calling this out as an intriguing observation; not trying to pick on anyone.
  - eloff 8y ago
    I've also noticed that. People are illogical.
  - TheSpiceIsLife 8y ago
    I don't believe that's a fair comparison. Firstly, marijuana taken internally has a long tradition of use. GMO's not so much. Admittedly, modern strains of marijuana may pose greater concerns. Secondly, legalisation of recreational drugs is, I'd argue, only tangentially related to the harm they may cause by using them. Take alcohol as an example. The legalisation of recreational drugs is, I'd argue, more about a) personal-sovereignty, and b) the harm caused by the war on drugs. For the record, I'm pro GMO when and where they makes sense, and also pro personal-sovereignty.
    - weberc2 8y ago
      GMOs have been consumed as a primary food source daily by hundreds of millions of people per year with no known health risks, even after extensive study. Cannabis has been used for a while, but it hasn’t received the same level of study and concerns have been raised (e.g., this article). I’ve got to give this one to the GMOs. > Secondly, legalisation of recreational drugs is, I'd argue, only tangentially related to the harm they may cause by using them. Take alcohol as an example. The legalisation of recreational drugs is, I'd argue, more about a) personal-sovereignty, and b) the harm caused by the war on drugs. How does “personal sovereignty” explain supporting prohibitions against GMOs? The opposition to the war on drugs but seems plausible.
  - rorykoehler 8y ago
    GMOs are the genetic equivalent to plastic in the ocean. Once it's in the wild it's damn hard to reverse the damage. Weed on the other hand you can just not consume.
    - weberc2 8y ago
      GMOs are already produced on a massive scale; any irreversible damage is already done. Further, this is true for any domesticated organism, not GMOs in particular. Besides, the argument I referenced was about health risks, not ecological damage.
docbrown 8y ago
>As I understand it THC aggravates symptoms in people predisposed to psychosis. This seems to be similar reactions to those who take doses of LSD and other psychedelic drugs.
- TheSpiceIsLife 8y ago
  Just to level to the playing field: This also seems to be the case for alcohol use. It stands to reason drug response follows a bell shaped curve, where most people fit in to the pleasant-effects most-of-the-time large area covered by the curve, and fewer people fall outside.

by galvin 8y ago

the-pigeon 8y ago

Which is one of the big problems with cannabis studies. THC is known as the "active" ingredient in cannabis. However we know it's definitely not the only one. There are 113 identified cannabinoids. Most are believed to have some effect. And there's terpenes that are believed to have effects as well. So the problem is that ever single bit of cannabis has different ratios of these chemicals. Even two plants with the exact same genetics grown in same conditions can have widely ranging ratios. Which potentially means widely ranging effects. The good thing is with legalization moving along we should see a lot more high quality studies that can help us figure this out. https://en.wikipedia.org/wiki/Cannabinoid https://en.wikipedia.org/wiki/Cannabinoid https://www.leafly.com/news/cannabis-101/terpenes-the-flavors-of-cannabis-aromatherapy https://www.leafly.com/news/cannabis-101/terpenes-the-flavor... http://www.ncsm.nl/english/what-is-medicinal-cannabis/active-ingredients#Terpenes http://www.ncsm.nl/english/what-is-medicinal-cannabis/active...

weberc2 8y ago
> The good thing is with legalization moving along we should see a lot more high quality studies that can help us figure this out. This is tangential, but it seems odd to me that many of the same people who are opposed to GMOs on the grounds that “science may have missed something” are okay with legalizing pot until science clearly demonstrates harm. Note that I’m not directing that at you (I don’t think you said anything like what I’m describing), but your quip made me think of it. I’m only calling this out as an intriguing observation; not trying to pick on anyone.
- eloff 8y ago
  I've also noticed that. People are illogical.
- TheSpiceIsLife 8y ago
  I don't believe that's a fair comparison. Firstly, marijuana taken internally has a long tradition of use. GMO's not so much. Admittedly, modern strains of marijuana may pose greater concerns. Secondly, legalisation of recreational drugs is, I'd argue, only tangentially related to the harm they may cause by using them. Take alcohol as an example. The legalisation of recreational drugs is, I'd argue, more about a) personal-sovereignty, and b) the harm caused by the war on drugs. For the record, I'm pro GMO when and where they makes sense, and also pro personal-sovereignty.
  - weberc2 8y ago
    GMOs have been consumed as a primary food source daily by hundreds of millions of people per year with no known health risks, even after extensive study. Cannabis has been used for a while, but it hasn’t received the same level of study and concerns have been raised (e.g., this article). I’ve got to give this one to the GMOs. > Secondly, legalisation of recreational drugs is, I'd argue, only tangentially related to the harm they may cause by using them. Take alcohol as an example. The legalisation of recreational drugs is, I'd argue, more about a) personal-sovereignty, and b) the harm caused by the war on drugs. How does “personal sovereignty” explain supporting prohibitions against GMOs? The opposition to the war on drugs but seems plausible.
- rorykoehler 8y ago
  GMOs are the genetic equivalent to plastic in the ocean. Once it's in the wild it's damn hard to reverse the damage. Weed on the other hand you can just not consume.
  - weberc2 8y ago
    GMOs are already produced on a massive scale; any irreversible damage is already done. Further, this is true for any domesticated organism, not GMOs in particular. Besides, the argument I referenced was about health risks, not ecological damage.

docbrown 8y ago

>As I understand it THC aggravates symptoms in people predisposed to psychosis. This seems to be similar reactions to those who take doses of LSD and other psychedelic drugs.

TheSpiceIsLife 8y ago
Just to level to the playing field: This also seems to be the case for alcohol use. It stands to reason drug response follows a bell shaped curve, where most people fit in to the pleasant-effects most-of-the-time large area covered by the curve, and fewer people fall outside.