6 ms·

What drugs specifically are in the "cocktail"? I could not access the paywalled paper. Gratefully fanzhang answered my question below: fanzhang:>The paper say

What drugs specifically are in the "cocktail"? I could not access the paywalled paper. Gratefully fanzhang answered my question below: fanzhang:>The paper says: Metformin, Psora-4, Rapamycin, Rifampicin, and Allantoin. Here's a 2017 article w/o paywall which identified the five drugs above and also the best combinations (for worms) at that time: "Rapamycin,rifampicin, Psora-4 cocktail doubles lifespan": https://alivebynature.com/rapamycinrifampicin-psora-4-cocktail-doubles-lifespan/ https://alivebynature.com/rapamycinrifampicin-psora-4-cockta... The article states that the most successful one(at that time) was rapamycin + rifampicin + allantoin, resulting in a doubling of mean lifespan.

wackro 8y ago
Well, this is just an article. The paper is here: https://www.sciencedirect.com/science/article/abs/pii/S1534580718306993 https://www.sciencedirect.com/science/article/abs/pii/S15345... I'm not sure if the paper mentions the drugs.
detaro 8y ago
The drugs are clearly listed in the paper, as has been mentioned here in the comments already.
lazerpants 8y ago
The drugs are listed in the actual paper. https://www.sciencedirect.com/science/article/pii/S1534580718306993?v https://www.sciencedirect.com/science/article/pii/S153458071...
chilledheat 8y ago
Did you read the article? "The drug rapamycin is currently administered following organ transplants to prevent the body's immune system from rejecting the transplanted organs, but previous experiments by other research groups showed that it extends the lifespan of many organisms, including the C. elegans worms, fruit flies and mice" Dr Gruber's team administered combinations of two or three compounds targeting different ageing pathways to C. elegans (worms).
- donquichotte 8y ago
  I'm not a biologist, but wouldn't an immunosuppressant's "life prolonging" effects be negated in a non-petri-dish-environment by bacterial, viral and fungal infections to the recepient?
- stochastic_monk 8y ago
  You provided some understanding from the article, which is appreciated. As a friendly reminder, the guidelines state: “Please don't insinuate that someone hasn't read an article. "Did you even read the article? It mentions that" can be shortened to "The article mentions that."”
  - morsmodr 8y ago
    Why would you think that the question immediately implies an insinuation? It is a perfectly normal question to ask based on data. Article gives info. First comment (now no longer the top comment) asks question on info, response from person who read the article - did you read the article? It is logical to me, I don't think there was any insinuation here, just asking for verification. Simple as that :) A better question in the first place would be - I read the article but am unable to figure out which are the drugs actually used as I do not have much background in Bio/Pharma science
    - dvfjsdhgfv 8y ago
      > Why would you think that the question immediately implies an insinuation? This may be culture-dependent, but I guess most people would feel it that way.
      - stochastic_monk 8y ago
        In my experience, the question is stronger than an insinuation, coming across as an accusation.
        morsmodr 8y ago
BurningFrog 8y ago
Ah yes, Metformin is strongly believed to extend human life span. I've been thinking about asking my doctor for a prescription.
- onetimemanytime 8y ago
  This makes sense. Glucose at above certain levels ruins cells, so Metformin lowers the glucose level. Asking the doc is key, you can't just read an article and try to find 4-5 meds to take each day :)
  - cgh 8y ago
    You can also eat a very low-carb diet. Restricting your carbs to foods like greens and berries will have the same effect without the need for a prescription. Gluconeogenesis is demand-driven. Of course, in the context of anti-aging, Metformin may have other beneficial effects outside of moderating glucose levels.
    - village-idiot 8y ago
      Fasting is also a good idea. It forces your body to kill off marginal cells for food, rather than leaving them to potentially become cancer.
      - _Schizotypy 8y ago
        Can you cite a source please? I would be very interested in reading it
        sushid 8y ago
        Not the parent but try searching online for fasting and autophagy. There are countless sources regarding this link. Another good recent study is the intestinal stem cell regenerative boost after a 24 hour fast in mice. One might say that the links are still not solid, but we do know that lowering glucose levels might be a good idea (hence the interest in metformin) and fasting/keto certainly achieves that without a drug.
baccheion 8y ago
Selegiline has also been associated with increased lifespan. I sometimes wonder if vitamin D's effect on blood sugar is comparable to metformin.

wackro 8y ago

Well, this is just an article. The paper is here: https://www.sciencedirect.com/science/article/abs/pii/S1534580718306993 https://www.sciencedirect.com/science/article/abs/pii/S15345... I'm not sure if the paper mentions the drugs.

detaro 8y ago

The drugs are clearly listed in the paper, as has been mentioned here in the comments already.

lazerpants 8y ago

The drugs are listed in the actual paper. https://www.sciencedirect.com/science/article/pii/S1534580718306993?v https://www.sciencedirect.com/science/article/pii/S153458071...

chilledheat 8y ago

Did you read the article? "The drug rapamycin is currently administered following organ transplants to prevent the body's immune system from rejecting the transplanted organs, but previous experiments by other research groups showed that it extends the lifespan of many organisms, including the C. elegans worms, fruit flies and mice" Dr Gruber's team administered combinations of two or three compounds targeting different ageing pathways to C. elegans (worms).

donquichotte 8y ago
I'm not a biologist, but wouldn't an immunosuppressant's "life prolonging" effects be negated in a non-petri-dish-environment by bacterial, viral and fungal infections to the recepient?
stochastic_monk 8y ago
You provided some understanding from the article, which is appreciated. As a friendly reminder, the guidelines state: “Please don't insinuate that someone hasn't read an article. "Did you even read the article? It mentions that" can be shortened to "The article mentions that."”
- morsmodr 8y ago
  Why would you think that the question immediately implies an insinuation? It is a perfectly normal question to ask based on data. Article gives info. First comment (now no longer the top comment) asks question on info, response from person who read the article - did you read the article? It is logical to me, I don't think there was any insinuation here, just asking for verification. Simple as that :) A better question in the first place would be - I read the article but am unable to figure out which are the drugs actually used as I do not have much background in Bio/Pharma science
  - dvfjsdhgfv 8y ago
    > Why would you think that the question immediately implies an insinuation? This may be culture-dependent, but I guess most people would feel it that way.
    - stochastic_monk 8y ago
      In my experience, the question is stronger than an insinuation, coming across as an accusation.
      - morsmodr 8y ago

BurningFrog 8y ago

Ah yes, Metformin is strongly believed to extend human life span. I've been thinking about asking my doctor for a prescription.

onetimemanytime 8y ago
This makes sense. Glucose at above certain levels ruins cells, so Metformin lowers the glucose level. Asking the doc is key, you can't just read an article and try to find 4-5 meds to take each day :)
- cgh 8y ago
  You can also eat a very low-carb diet. Restricting your carbs to foods like greens and berries will have the same effect without the need for a prescription. Gluconeogenesis is demand-driven. Of course, in the context of anti-aging, Metformin may have other beneficial effects outside of moderating glucose levels.
  - village-idiot 8y ago
    Fasting is also a good idea. It forces your body to kill off marginal cells for food, rather than leaving them to potentially become cancer.
    - _Schizotypy 8y ago
      Can you cite a source please? I would be very interested in reading it
      - sushid 8y ago
        Not the parent but try searching online for fasting and autophagy. There are countless sources regarding this link. Another good recent study is the intestinal stem cell regenerative boost after a 24 hour fast in mice. One might say that the links are still not solid, but we do know that lowering glucose levels might be a good idea (hence the interest in metformin) and fasting/keto certainly achieves that without a drug.

baccheion 8y ago

Selegiline has also been associated with increased lifespan. I sometimes wonder if vitamin D's effect on blood sugar is comparable to metformin.