4 ms·

> The most common adverse reactions in patients taking Xofluza included diarrhea and bronchitis. I wish the article listed the frequency or likelihood of getti

> The most common adverse reactions in patients taking Xofluza included diarrhea and bronchitis. I wish the article listed the frequency or likelihood of getting these reactions. Given the choice between flu and bronchitis, I'll take the flu.

refurb 8y ago
It's in the prescribing information.[1] Adverse event - Xofluza(%) - Placebo(%) Diarrhea - 3% - 5% [higher in placebo] Bronchitis - 2% - 4% [higher in placebo] The FDA requires that the manufacturer list the most common adverse events, even if they are unrelated to the drug in question. [1]https://www.gene.com/download/pdf/xofluza_prescribing.pdf https://www.gene.com/download/pdf/xofluza_prescribing.pdf
- aaaaaardvark 8y ago
  Whoa stay away from that placebo.
  - eli 8y ago
    Interestingly, placebos have been getting stronger and more effective over the years. It’s a real bummer for people running clinical trials. https://www.scientificamerican.com/article/placebo-effect-grows-in-u-s-thwarting-development-of-painkillers/ https://www.scientificamerican.com/article/placebo-effect-gr...
    - leekyle333 8y ago
      If you're ever board and you want to watch something on placebos I highly recommend watching this lecture by Dr. Irving Kirsch. Placebos are pretty nuts and probably really undervalued. https://www.youtube.com/watch?v=ISptt3CRAqc&t=15s https://www.youtube.com/watch?v=ISptt3CRAqc&t=15s
      - acct1771 8y ago
        I'd rather die than live a lie.
    - hn_throwaway_99 8y ago
      Wow, what an interesting study! Especially since the effect was only seen in the US.
bsder 8y ago
Then don't read the side effects for aspirin ...
qwerty456127 8y ago
Chances are you are going to get diarrhea and bronchitis anyway if you get flu, whether you take the cure or not. I would be more curious about how well does it play together with something like ambroxol hydrochloride - I used to get bronchitis as a complication every time I get cold in the past but as soon as I've discovered ambroxol hydrochloride I've forgotten about ever having bronchitis as a bad dream.
- giarc 8y ago
  Diarrhea is not very common in patients with influenza. Perhaps a little more in children but not so much in adults.
wahern 8y ago
The flu can also cause bronchitis. More often than not I end up with bronchitis after a severe flu or cold. I don't even bother with the doctor anymore (unless I have a fever) because I'm not interested in the codeine and I can just buy Primatene (ephedrine + guaifenesin) over the counter. Both my doctor and a pharmacist have admitted they could do no better.
- craftyguy 8y ago
  > unless I have a fever How often do you get the flu (actual flu, not a bad cold) and not have a fever? I've only had the flu once in my life (30-something years), and it was like being hit by a bus, having said bus park on your body, and having said bus catch on fire and slowly burn.
  - wahern 8y ago
    I meant if I have a fever with persistent, unproductive coughing after the flu itself has seemingly subsided. A fever would suggest a lung infection, either causing the bronchitis or vice-versa, but which in any event might require antibiotics lest it degenerate into pneumonia. I've had pneumonia at least twice as an adolescent, but which went untreated for awhile because it was typical for me to have prolonged coughing and lethargy after a respiratory illness. So while I'll treat my own bronchitis, I have to be mindful that the bronchitis could be secondary, or could have resulted in an infection.

refurb 8y ago

It's in the prescribing information.[1] Adverse event - Xofluza(%) - Placebo(%) Diarrhea - 3% - 5% [higher in placebo] Bronchitis - 2% - 4% [higher in placebo] The FDA requires that the manufacturer list the most common adverse events, even if they are unrelated to the drug in question. [1]https://www.gene.com/download/pdf/xofluza_prescribing.pdf https://www.gene.com/download/pdf/xofluza_prescribing.pdf

aaaaaardvark 8y ago
Whoa stay away from that placebo.
- eli 8y ago
  Interestingly, placebos have been getting stronger and more effective over the years. It’s a real bummer for people running clinical trials. https://www.scientificamerican.com/article/placebo-effect-grows-in-u-s-thwarting-development-of-painkillers/ https://www.scientificamerican.com/article/placebo-effect-gr...
  - leekyle333 8y ago
    If you're ever board and you want to watch something on placebos I highly recommend watching this lecture by Dr. Irving Kirsch. Placebos are pretty nuts and probably really undervalued. https://www.youtube.com/watch?v=ISptt3CRAqc&t=15s https://www.youtube.com/watch?v=ISptt3CRAqc&t=15s
    - acct1771 8y ago
      I'd rather die than live a lie.
  - hn_throwaway_99 8y ago
    Wow, what an interesting study! Especially since the effect was only seen in the US.

bsder 8y ago

Then don't read the side effects for aspirin ...

qwerty456127 8y ago

Chances are you are going to get diarrhea and bronchitis anyway if you get flu, whether you take the cure or not. I would be more curious about how well does it play together with something like ambroxol hydrochloride - I used to get bronchitis as a complication every time I get cold in the past but as soon as I've discovered ambroxol hydrochloride I've forgotten about ever having bronchitis as a bad dream.

giarc 8y ago
Diarrhea is not very common in patients with influenza. Perhaps a little more in children but not so much in adults.

wahern 8y ago

The flu can also cause bronchitis. More often than not I end up with bronchitis after a severe flu or cold. I don't even bother with the doctor anymore (unless I have a fever) because I'm not interested in the codeine and I can just buy Primatene (ephedrine + guaifenesin) over the counter. Both my doctor and a pharmacist have admitted they could do no better.

craftyguy 8y ago
> unless I have a fever How often do you get the flu (actual flu, not a bad cold) and not have a fever? I've only had the flu once in my life (30-something years), and it was like being hit by a bus, having said bus park on your body, and having said bus catch on fire and slowly burn.
- wahern 8y ago
  I meant if I have a fever with persistent, unproductive coughing after the flu itself has seemingly subsided. A fever would suggest a lung infection, either causing the bronchitis or vice-versa, but which in any event might require antibiotics lest it degenerate into pneumonia. I've had pneumonia at least twice as an adolescent, but which went untreated for awhile because it was typical for me to have prolonged coughing and lethargy after a respiratory illness. So while I'll treat my own bronchitis, I have to be mindful that the bronchitis could be secondary, or could have resulted in an infection.