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There’s definitely a role for mitochondrial dysfunction as well. If you store excess fat in the liver, consume sugar while overfeeding (eating at surplus of TDE
by 0x8BADF00D 8y ago
There’s definitely a role for mitochondrial dysfunction as well. If you store excess fat in the liver, consume sugar while overfeeding (eating at surplus of TDEE), your mitochondria will start to dysfunction w.r.t. energy.
- gumby 8y agowhat's the mechanism here?
- 0x8BADF00D 8y agoIANAD, but based on the literature I’ve read, there are two negative feedback loops[0][1]. The first involves skeletal muscle uptake of insulin. Mitochondria in skeletal muscle will not efficiently use glycogen stores. Insulin is released inappropriately by the pancreas due to excess glucose. Body thinks we are in a catabolic state (we must be because insulin was released) so fatty acid oxidation is inhibited. Liver converts lactate into glucose, exacerbating the original mitochondrial dysfunction (what happens when you introduce too much energy into a system that cannot use it?). The second negative feedback loop involves insulin/glucagon and leptin/ghrelin. Since your body thinks it’s starving (when in reality it cannot use energy efficiently), ghrelin will be secreted. So you keep getting hungry, no matter how much you eat, and insulin spikes as a result of insulin resistance. Leptin is effectively silenced, removing the body’s ability to feel sated. [0]http://semmelweis.hu/biokemia/files/2014/09/EN_con_INS12_Mitochondria-and-diabetes2005.pdf http://semmelweis.hu/biokemia/files/2014/09/EN_con_INS12_Mit... [1]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824521/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824521/