The layout of the keyboard doesn't really matter. The Typematrix can send the regular key-codes like any ordinary ANSI keyboard, or it can mix them up so that

The layout of the keyboard doesn't really matter. The Typematrix can send the regular key-codes like any ordinary ANSI keyboard, or it can mix them up so that it acts as a Dvorak keyboard even if the OS is set up on Qwerty. But really, the layout should be set by the OS, not by the keyboard. Personally, I use Bépo: http://bepo.fr http://bepo.fr It's a Dvorak-like layout optimized for French. It works well for English, though (far better than Qwerty, anyway). If your native language isn't English and uses Latin letters, you may want to look for a layout optimized for it.