6 ms·

The full list is not in the article, and the paper is behind a paywall, but most of the 'vitamins' seem to be listed in the supplemental materials which are sti

The full list is not in the article, and the paper is behind a paywall, but most of the 'vitamins' seem to be listed in the supplemental materials which are still free: http://www.pnas.org/highwire/filestream/831622/field_highwire_adjunct_files/0/pnas.1809045115.sapp.pdf http://www.pnas.org/highwire/filestream/831622/field_highwir... Some things I thought would be there are missing, like carnosine.

autojoechen 8y ago
In case anyone else is also going through the article for the list: Vitamin K, Selenium, Vitamin D, Taurine, Ergothioneine, Pyrroloquinoline quinone, Queuine, Carotenoids, Lutein and Zeaxanthin, Lycopene, alpha and beta-Carotene, Astaxanthin
- vimota 8y ago
  And some natural sources: https://twitter.com/foundmyfitness/status/1052981669655965698 https://twitter.com/foundmyfitness/status/105298166965596569...
- nikkwong 8y ago
  Does the paper also talk about proper dosages if one wants to supplement with these vitamins? I know it says 4000 UI for vitamin D but don't see any mention for dosages of vitamin K.
  - baccheion 8y ago
    10 IU D3 : 2 mcg+ MK-4. Vitamin K2 MK-4 becomes active at 1.5 milligrams, with some taking 5-9 mg daily: https://examine.com/supplements/vitamin-k/ https://examine.com/supplements/vitamin-k/.
- baccheion 8y ago
  AOR Ortho-Core has many of these and is especially great when combined with Life Extension D + K and Doctor's Best High Absorption Magnesium.
  - WalterSear 8y ago
    So does the vegetable section of the grocery store fwiw.
    - baccheion 8y ago
      Getting as much as possible from real food tends to be preferred.
sytelus 8y ago
I have only one question: How did they validated this? For grand claims like this you need to run controlled experiment for many years. The reason I say this is because typically these studies are funded by commercial interests with the goal to cite these studies in their marketing material.
- barry-cotter 8y ago
  It’s nutrition. You almost can’t run long term randomised experiments patient compliance is so low. Take it as interesting at best like the rest of the field that told us salt was bad for us, that dietary cholesterol effected serum cholesterol and trans fats were healthier than polyunsaturated (margarine vs butter).
  - sizzle 8y ago
    Also how do you control for diversity of bacteria in our guts and variation of metabolism on an individual basis?
- jmk343 8y ago
  It's more of a hypothesis paper by a retired scientist. Bruce Ames, the author used to do experiments on vitamin and mineral deficiencies in animals 20+ years ago. What he found was things like increased DNA strand breaks. Nothing positive was found in terms of longevity or healthspan when supplementing excess anti-oxidants. It's possible to search Ames B[author] on pubmed to see his old publications. "Maybe some these things would extend healthspan if people have a less than optimal diet." ...or that maybe some novel and expensive things might have small health impacts. Not that they do otherwise, or that there is rigorous experiments demonstrating so. I think some people are eagerly clamoring to supplement based on this list, which is just fueling the 30bn dollar a year supplement industry. https://www.nytimes.com/2018/08/01/style/wellness-industrial-complex.html https://www.nytimes.com/2018/08/01/style/wellness-industrial... Why not fund basic research into age related disease instead? i.e. [ https://www.lifespan.io/the-rejuvenation-roadmap/ https://www.lifespan.io/the-rejuvenation-roadmap/, http://dogagingproject.com http://dogagingproject.com, http://sens.org http://sens.org ]
RachelF 8y ago
Be careful, especially with dosage; meta studies[1] have linked increased consumption of vitamins to a shorter life. [1]https://sciencebasedmedicine.org/vitamins-and-cancer-risk/ https://sciencebasedmedicine.org/vitamins-and-cancer-risk/
- WalterSear 8y ago
  Increased consumption of vitamin pills. Consuming more plants, and more of specific plants, is the appropriate way to increase the presence of these micronutrients in one's diet.

autojoechen 8y ago

In case anyone else is also going through the article for the list: Vitamin K, Selenium, Vitamin D, Taurine, Ergothioneine, Pyrroloquinoline quinone, Queuine, Carotenoids, Lutein and Zeaxanthin, Lycopene, alpha and beta-Carotene, Astaxanthin

vimota 8y ago
And some natural sources: https://twitter.com/foundmyfitness/status/1052981669655965698 https://twitter.com/foundmyfitness/status/105298166965596569...
nikkwong 8y ago
Does the paper also talk about proper dosages if one wants to supplement with these vitamins? I know it says 4000 UI for vitamin D but don't see any mention for dosages of vitamin K.
- baccheion 8y ago
  10 IU D3 : 2 mcg+ MK-4. Vitamin K2 MK-4 becomes active at 1.5 milligrams, with some taking 5-9 mg daily: https://examine.com/supplements/vitamin-k/ https://examine.com/supplements/vitamin-k/.
baccheion 8y ago
AOR Ortho-Core has many of these and is especially great when combined with Life Extension D + K and Doctor's Best High Absorption Magnesium.
- WalterSear 8y ago
  So does the vegetable section of the grocery store fwiw.
  - baccheion 8y ago
    Getting as much as possible from real food tends to be preferred.

sytelus 8y ago

I have only one question: How did they validated this? For grand claims like this you need to run controlled experiment for many years. The reason I say this is because typically these studies are funded by commercial interests with the goal to cite these studies in their marketing material.

barry-cotter 8y ago
It’s nutrition. You almost can’t run long term randomised experiments patient compliance is so low. Take it as interesting at best like the rest of the field that told us salt was bad for us, that dietary cholesterol effected serum cholesterol and trans fats were healthier than polyunsaturated (margarine vs butter).
- sizzle 8y ago
  Also how do you control for diversity of bacteria in our guts and variation of metabolism on an individual basis?
jmk343 8y ago
It's more of a hypothesis paper by a retired scientist. Bruce Ames, the author used to do experiments on vitamin and mineral deficiencies in animals 20+ years ago. What he found was things like increased DNA strand breaks. Nothing positive was found in terms of longevity or healthspan when supplementing excess anti-oxidants. It's possible to search Ames B[author] on pubmed to see his old publications. "Maybe some these things would extend healthspan if people have a less than optimal diet." ...or that maybe some novel and expensive things might have small health impacts. Not that they do otherwise, or that there is rigorous experiments demonstrating so. I think some people are eagerly clamoring to supplement based on this list, which is just fueling the 30bn dollar a year supplement industry. https://www.nytimes.com/2018/08/01/style/wellness-industrial-complex.html https://www.nytimes.com/2018/08/01/style/wellness-industrial... Why not fund basic research into age related disease instead? i.e. [ https://www.lifespan.io/the-rejuvenation-roadmap/ https://www.lifespan.io/the-rejuvenation-roadmap/, http://dogagingproject.com http://dogagingproject.com, http://sens.org http://sens.org ]

RachelF 8y ago

Be careful, especially with dosage; meta studies[1] have linked increased consumption of vitamins to a shorter life. [1]https://sciencebasedmedicine.org/vitamins-and-cancer-risk/ https://sciencebasedmedicine.org/vitamins-and-cancer-risk/

WalterSear 8y ago
Increased consumption of vitamin pills. Consuming more plants, and more of specific plants, is the appropriate way to increase the presence of these micronutrients in one's diet.