Will it be terribly different than how US states that have legalized marijuana interface with federal governmental entities? Plenty of folks in Colorado, Oregon

Will it be terribly different than how US states that have legalized marijuana interface with federal governmental entities? Plenty of folks in Colorado, Oregon, Washington, some of the New England States, and California work for the federal government and have to tell them that they do not use marijuana. Similar with airline pilots, etc based out of these States.