Ok but what makes a certain meme have enough power that it then has fecundity/fidelity? There must be a resonance between powerful memes and 'human nature' or e

Ok but what makes a certain meme have enough power that it then has fecundity/fidelity? There must be a resonance between powerful memes and 'human nature' or else they surely wouldn't propagate (e.g. fear of death, in the case of the 'hell' meme). I suppose what I'm wondering is: is this meme making people fret that they might actually be NPCs? It must be resonating with people or else there wouldn't be uproar.