As a theory of Alzheimer's, I'm not sure how useful the Bredesen protocol is. The APP pathway is at its core, but there are thousands of components acting in co

As a theory of Alzheimer's, I'm not sure how useful the Bredesen protocol is. The APP pathway is at its core, but there are thousands of components acting in complex ways. Theories need to be falsifiable; it'd be hard to refute Bredesen since it's a sort of Gestalt of the entire field. As a treatment though, it seems excellent! We know thousands of tiny details about the Alzheimer's process, what better intervention in a complex, poorly-understood disease than to use everything we've got? Bredesen has published successful trials of this "protocol;" that's all we really need to bear in mind. After all, many drugs are approved despite the mechanisms not being known. Figuring out the mechanism first failed (as all the blockbuster wipeouts have shown us with AD.) Throw the kitchen sink at it, if you can afford the medical bills.