A single S-curve will not. However, completion of one line of technological development often unlocks new possibilities. Over the last several centuries, we'v

A single S-curve will not. However, completion of one line of technological development often unlocks new possibilities. Over the last several centuries, we've ridden many S-curves of varying scales; it has certainly hurt when a particularly large S-curve, such as energy extraction or sequential computing speed, has saturated, but there have always been more than enough promising underexplored possibilities to keep humanity's brightest minds occupied. Both the known laws of physics and the amount of biological activity we still haven't replicated indicate that this state of affairs won't end within the next century. (We might stop exploring due to some sort of apocalypse, of course, but that won't be because there was nothing meaningful left to discover.)