The way I read this, the first two trials did not bring enough evidence towards the drug working, but they did provide some evidence. In the end, all three expe

The way I read this, the first two trials did not bring enough evidence towards the drug working, but they did provide some evidence. In the end, all three experiments taken together provide pretty massive evidence that the drug actually works, way below 0.05. Of course, this all comes crashing down if the first two experiments happen to provide contrary evidence (that is, evidence the drug does not work). This would cancel out the results of the final trial somewhat, and not taking this into account is clearly cheating by publication bias.