That's right - the Huffman tree was built based on the base frequency of use, which actually varies depending on what type of organism you're sequencing[1]. [1

That's right - the Huffman tree was built based on the base frequency of use, which actually varies depending on what type of organism you're sequencing[1]. [1] https://en.wikipedia.org/wiki/GC-content#Among-genome_variation https://en.wikipedia.org/wiki/GC-content#Among-genome_variat...