4 ms·

This was already done once, if I'm not mistaken, in Japan in 2004: https://www.sciencemag.org/news/2004/04/mouse-two-mothers https://www.sciencemag.org/news/20

• jhbadger 8y ago
  This is not exactly the same. That used the genetic information from two mouse egg cells. The Chinese study is using haploid mouse embryonic stem cells with genetic contribution from either an mouse egg (successful) or mouse sperm (unsuccessful).
  • Old_Thrashbarg 8y ago
    Can you explain a difference in more lay terms? The experiment that @ppeetteerr points out, is that not a baby mouse created? And that baby is from the genetic information of 2 mothers? You also mentioned the Japanese study used egg cells, while this one uses haploid cells... aren't egg cells haploid?
    • jhbadger 8y ago
      Yes, in both cases baby mice were made. And yes, eggs and sperm are haploid. But the difference here is that the starting cells were embryonic stem cells -- that is, they are cells that are "pluripotent" -- that is cells that haven't yet been programmed to be any particular cell type. So it is a more difficult accomplishment than just working with two eggs.
• vilhelm_s 8y ago
  The paper says > Using immature oocytes with a deletion of the H19 imprinted region, Kono et al. (2004) produced the first mice from two mothers [...] bipaternal reproduction, which has only been found in specific fish (Corley-Smith et al., 1996), has not been achieved in mammals until now. so I guess a mouse with two mothers existed before, and they now also made a mouse with two fathers.