3 ms·
> all antidepressants were more effective than placebo Comparing them to placebo isn't appropriate, you need to compare them with an active placebo and only lo
by Alex3917 8y ago
> all antidepressants were more effective than placebo
Comparing them to placebo isn't appropriate, you need to compare them with an active placebo and only look at studies that continue longer than two years. Of which there are all of like 2 studies.
- thomasfedb 8y agoYou should remember that we do research on real humans. Sometime this means we can't have the evidence we'd like to have. Active placebos are designed to cause detriment to the patient - to cause side effects to convince them they're not on the placebo. Getting ethics approval to do randomised trials in depressed patients is hard enough without harming your control group.
- Alex3917 8y ago> Active placebos are designed to cause detriment to the patient Patients on active placebos have reduced depression symptoms as compared with patients on non-active placebos.