5 ms·

If the naked mole rat does not age in terms of negative consequences of age, what makes them die at 30?

zogwarg 8y ago
Have not read the paper I assume that if you had a large enough mole rat population you would observe some of them to live beyond 30.
- zogwarg 8y ago
  The total compiled sample size is rather small. 3848
- zogwarg 8y ago
  Also we have mole rats in captivity above 30 years at this moment. I guess we only have had size-able mole rat population for around 30 years.
thedailymail 8y ago
The authors address this this to some degree in the Discussion. See the para beginning "Indeed, naked mole-rat mortality was less consistent with a typical Gompertz model of hazard than it was with an exponential decay model, with a constant probability of decay (death) defining a species’ half-life."
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Nasrudith 8y ago
What makes them die younger is the real question. Their curve is pretty flat as a trend line (although with plenty of peaks and valleys) and seems to start at 600 day old mouse mortality rates. Although they are also infamously inbred. I wonder if it would be possible to breed for lifespan by breeding only the 'elders' among them or if it would do about as much good as breeding for resistance to gunshots - outside circumstances not influencible.
- solveit 8y ago
  It works on fruit flies, see Rose, M. Laboratory Evolution of Postponed Senescence in Drosophila melanogaster. Evolution (1984), where the lifespan was doubled. So this certainly works in principle. For longer lived species I expect it will still work, but it would take hundreds to thousands of years to breed for even a few dozen generations.
  - rincebrain 8y ago
    I would be concerned with secondary effects of aging on viability of gametes and chances of exotic conditions - doing this over any large span of generations would probably (temporarily?) yield a much higher mortality rate until we figured out the best ratio of increased parent lifespan to increased child mortality.
    - adrianN 8y ago
      With humans you probably wouldn't want to wait with the breeding until the parents are old, but select breeding pairs based on the longevity of their (great-)grandparents. At least until you figure out useful biomarkers that reliably predict longevity already at the age of twenty or so.
- interfixus 8y ago
  Of course you can breed for resistance to gunshots. Size, hardened skin, extreme speed of ducking reflex, regenerative capacity, spiderlike weaving ability etc. etc. Long term project, but in principle.
- halfdan 8y ago
  > I wonder if it would be possible to breed for lifespan by breeding only the 'elders' among them You wouldn't want to breed the 'elders' but the offspring of 'elderly' naked mole rats.
tejtm 8y ago
The same things that make them die at three years old. The point is the rate of those things which kill, does not increase as much with age as it does with the rest of us mammals.

Have not read the paper I assume that if you had a large enough mole rat population you would observe some of them to live beyond 30.

zogwarg 8y ago
The total compiled sample size is rather small. 3848
zogwarg 8y ago
Also we have mole rats in captivity above 30 years at this moment. I guess we only have had size-able mole rat population for around 30 years.

thedailymail 8y ago

The authors address this this to some degree in the Discussion. See the para beginning "Indeed, naked mole-rat mortality was less consistent with a typical Gompertz model of hazard than it was with an exponential decay model, with a constant probability of decay (death) defining a species’ half-life."

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Nasrudith 8y ago

What makes them die younger is the real question. Their curve is pretty flat as a trend line (although with plenty of peaks and valleys) and seems to start at 600 day old mouse mortality rates. Although they are also infamously inbred. I wonder if it would be possible to breed for lifespan by breeding only the 'elders' among them or if it would do about as much good as breeding for resistance to gunshots - outside circumstances not influencible.

solveit 8y ago
It works on fruit flies, see Rose, M. Laboratory Evolution of Postponed Senescence in Drosophila melanogaster. Evolution (1984), where the lifespan was doubled. So this certainly works in principle. For longer lived species I expect it will still work, but it would take hundreds to thousands of years to breed for even a few dozen generations.
- rincebrain 8y ago
  I would be concerned with secondary effects of aging on viability of gametes and chances of exotic conditions - doing this over any large span of generations would probably (temporarily?) yield a much higher mortality rate until we figured out the best ratio of increased parent lifespan to increased child mortality.
  - adrianN 8y ago
    With humans you probably wouldn't want to wait with the breeding until the parents are old, but select breeding pairs based on the longevity of their (great-)grandparents. At least until you figure out useful biomarkers that reliably predict longevity already at the age of twenty or so.
interfixus 8y ago
Of course you can breed for resistance to gunshots. Size, hardened skin, extreme speed of ducking reflex, regenerative capacity, spiderlike weaving ability etc. etc. Long term project, but in principle.
halfdan 8y ago
> I wonder if it would be possible to breed for lifespan by breeding only the 'elders' among them You wouldn't want to breed the 'elders' but the offspring of 'elderly' naked mole rats.

tejtm 8y ago

The same things that make them die at three years old. The point is the rate of those things which kill, does not increase as much with age as it does with the rest of us mammals.