An important difference in my mind is between designing a web application vs designing a web document. In the document case, it is possible to mostly keep the

An important difference in my mind is between designing a web application vs designing a web document. In the document case, it is possible to mostly keep the document semantic and apply styling via CSS. It matches the content/style separation well. For web applications, I really like tailwind-like approaches, for multiple reasons: * changing the style globally is probably hard anyway without adapting the HTML as well (as in the app case, often lots of other things depend on margins etc for example and you have a lot less uniformity/more special cases than in the document case) * because there is less uniformity, the reuse aspect of the traditional content/presentation split is greatly reduced anyway * web apps often use component based frameworks already, so you still get reusable components