I have written applications weighing in at about 10k lines of code (not huge, but big enough to have to manage some complexity) using LispWorks. I doubt I would

I have written applications weighing in at about 10k lines of code (not huge, but big enough to have to manage some complexity) using LispWorks. I doubt I would have problems writing the same software in guile. I don't really understand which inadequacies you mean. The only thing I really miss is conditions and restarts (which is a pretty big downside) and how integrated CLOS is (and the fact that LW pre-populates the CLOS caches is pretty neat!)