I'm not certain about CUDA drivers and whether this sort of thing work "just work" via the Nix package manager on GuixSD. That sounds like you might need to rec

I'm not certain about CUDA drivers and whether this sort of thing work "just work" via the Nix package manager on GuixSD. That sounds like you might need to recompile kernel headers or the like. Re: the comment about the Guix kernel and blobs: Guix uses the linux-libre kernel which has blobs removed. BUT you can use a custom kernel on Guix, so you could use a blobby kernel, but you would have to configure it. If you poke around, you can find examples of people doing this, e.g.: https://gist.github.com/TeMPOraL/306bbb7c627ab0d32fa84af831963563 https://gist.github.com/TeMPOraL/306bbb7c627ab0d32fa84af8319... But, in general, the standalone Nix package manager (and the standalone Guix package manager, for that matter) are designed to work as isolated units, not depending as much on the 'host' system, so lots of stuff does 'just work' regardless of whether the host distro is GuixSD or Debian or Void or Arch or whatever.