I have never (luckily) had any problems with RSI, but have taken the time to learn layouts which hide special keys under the home row, accesible with combinatio

I have never (luckily) had any problems with RSI, but have taken the time to learn layouts which hide special keys under the home row, accesible with combination of the Alt gr key. Have you had any experience with that and how it impacts on RSI? From my perspective it should do at least an impact since I rarely move from home row even if I do a lot of programming.