I'll give my own experience here. I switched to Dvorak by using a model M with movable key caps back when I was a teenager. It really was one of the most frust

I'll give my own experience here. I switched to Dvorak by using a model M with movable key caps back when I was a teenager. It really was one of the most frustrating experiences with muscle memory I have ever had--in fact it felt painful to receive continual mismatch of intent and results. I think it took me 2 weeks to write sentences without conscious pain, and about 3 months to get to a moderate speed. Even so, I still type dvorak for more than a decade now. My writing speed isn't really comparably faster with dvorak, but I do believe that it does reduce wrist strain. Ortholinear layouts further reduce some strain for me. When it comes to QWERTY, I still use it plenty on touch screens, and as a touch typist, I can still do it if I'm on a cheap logitech rubber dome keyboard. Though after a short while I feel like muscles are strained in my hands on physical keyboards. It is near impossible for me to type QWERTY on a mechanical keyboard or a macbook keyboard. The touch feel I have is so attuned to that layout (despite not having the legends on the key caps in dvorak) that I am continually making mistakes or reverting back to dvorak mid sentence. I don't regret my decision at all, though my coworkers are intimidated by it.