5 ms·
Can we update the title to reflect the research by adding "in mice" at the end of it? The effect of calorie restriction on aging in rodents has been known sinc
by fabricexpert 8y ago
Can we update the title to reflect the research by adding "in mice" at the end of it?
The effect of calorie restriction on aging in rodents has been known since the 1930s. Which does not diminish the value of identifying the precise molecule that triggers this, but it does mean that this shouldn't necessarily be used as justification for a fasting diet.
"It has been known since the 1930s that reducing the number of calories fed to laboratory rodents increases their life spans. The life extension varies for each species, but on average there was a 30–40% increase in life span in both mice and rats.[30] In late adulthood, acute CR partially or completely reverses age-related alterations of liver, brain and heart proteins, and mice placed on CR at 19 months of age show an increases in life span.[78] "
https://en.wikipedia.org/wiki/Calorie_restriction https://en.wikipedia.org/wiki/Calorie_restriction
- ransom1538 8y agoHere is one monkey on an unrestricted diet and one monkey on a restricted diet years later: http://www.slate.com/articles/health_and_science/medical_examiner/2012/08/calorie_restriction_and_longevity_monkey_study_shows_hunger_doesn_t_increase_longevity_but_type_of_food_does_.html http://www.slate.com/articles/health_and_science/medical_exa...
- lukeschlather 8y agoThat article in its entirety is interesting, because there are not two but four monkeys from two different studies. Two on "restricted diets," and two on "unrestricted diets." In one study they fed both monkeys a highly processed diet of 30% sucrose. In the other study they fed both monkeys a less processed diet of 4% sucrose. The monkey with the poor health outcome was the one allowed to eat as much as it wanted of the highly processed 30% sucrose diet. So the "calorie restriction" seems to more likely just mean "don't eat more than 4% sugar, unless you are on an extremely calorie restricted diet."
- kevin_thibedeau 8y agoThis only applies if you live a sedentary life with nothing to do all day. You can't draw any conclusions beyond that.
- flatb 8y agoI'm no expert, and I might be wrong, but generally I would argue against extracting conclusions (even layman conclusions) from two studies of a different species (!) with a sample size of 2 (!!!)
- deleted 8y ago[deleted]
- vlg 8y agoIt has been shown that longer lives occur in many species, from yeasts and c.elegans, to primates. Pubmed fetches lots of articles (arguing for both sides) given a search like 'caloric restriction aging'
- deleted 8y ago[deleted]