There is a line of reasoning (and evidence in mice) that the body seems to be designed to operate in starvation mode (e.g. calorie restriction). One line of tho

There is a line of reasoning (and evidence in mice) that the body seems to be designed to operate in starvation mode (e.g. calorie restriction). One line of thought behind this is that food abundance results in signalling along certain metabolic pathways that have not experienced heavy evolutionary pressure.