How does this work with other essential arrow combos that already require many modifiers, such as Alt+Left=Back, Shift+Arrow=selection, Ctrl+Up/Down=scrolling,

How does this work with other essential arrow combos that already require many modifiers, such as Alt+Left=Back, Shift+Arrow=selection, Ctrl+Up/Down=scrolling, Ctrl+Left for jumping one word, Shift+Ctrl+Arrow for selecting one word, Win+Shift+Left=moving window to next screen, etc. Now i instead have to do do do Modifier+Win+Shift+I? Modifier seems to be a cheapo button also unless you want to sacrifice having space on both sides.