Pre-publication registration of trials has happened. The major journals agreed they would only publish trials that were registered prior to publication. There a

Pre-publication registration of trials has happened. The major journals agreed they would only publish trials that were registered prior to publication. There are sites for this (www.clinicaltrials.gov). Unfortunately, I saw a paper recently which found that almost half of registered trials had significant differences between the registered and published methodologies, and no one was checking on this very carefully.