A potentially bigger issue with ibuprofen is that it increases heart attack and stroke risk, which acetaminophen doesn't do [0]. Plain old aspirin is probably t

A potentially bigger issue with ibuprofen is that it increases heart attack and stroke risk, which acetaminophen doesn't do [0]. Plain old aspirin is probably the safest drug. Its main risk factors are that it can cause stomach problems, it's ototoxic, and some people are allergic to it. [0] https://www.health.harvard.edu/blog/fda-strengthens-warning-that-nsaids-increase-heart-attack-and-stroke-risk-201507138138 https://www.health.harvard.edu/blog/fda-strengthens-warning-...