3 ms·

If anyone has been looking at TauRX's phase 3 trials[1], methylene blue is ridiculously cheap, has been around for 100 years and stops Alzheimers progression be

If anyone has been looking at TauRX's phase 3 trials[1], methylene blue is ridiculously cheap, has been around for 100 years and stops Alzheimers progression better than any other drug. Tau is working on a slightly modified form that is basically putting it in a capsule and they'll sell it for $50 a pill probably, but that's the only way that anyone will believe it actually works. Methylene blue is a potent antimicrobial that easily penetrates the blood brain barrier, so it working so well would be consistent with Alzheimers being an infectious disease. [1]https://content.iospress.com/download/journal-of-alzheimers-disease/jad170560?id=journal-of-alzheimers-disease%2Fjad170560 https://content.iospress.com/download/journal-of-alzheimers-...

delbel 8y ago
thanks for your post. That would be funny if the cure is to drink the "Methylene Blue Kool Aid"
tcj_phx 8y ago
Methylene blue is also an monoamine oxidase inhibitor. I add it to my dog’s food to boost her metabolism. She blew her knee out a year ago (common injury for large 10yo dogs) but has mostly recovered without the surgery the vet said she’d probably need. (I use a variety of interventions with her.) Methylene blue should not be combined with the later anti-depressants that focus more on serotonin (SSRIs, etc.), as this can cause serotonin toxicity: https://www.apsf.org/article/methylene-blue-and-the-risk-of-serotonin-toxicity/ https://www.apsf.org/article/methylene-blue-and-the-risk-of-... > Tau is working on a slightly modified form that is basically putting it in a capsule and they'll sell it for $50 a pill probably, but that's the only way that anyone will believe it actually works. Patent medicines [1] are still as popular as they ever were. Science made some inroads in the early 20th century, before the hucksters regrouped, with new prescription-only FDA approved nostrums. [1] https://en.m.wikipedia.org/wiki/Patent_medicine https://en.m.wikipedia.org/wiki/Patent_medicine
mrtnmcc 8y ago
Other studies of mild to moderate Alzheimer's patients showed no improvement with Methylene blue, https://www.alzforum.org/news/conference-coverage/first-phase-3-trial-tau-drug-lmtm-did-not-work-period https://www.alzforum.org/news/conference-coverage/first-phas... Also I'd generally be more skeptical as the green urine it produces could be a strong placebo enhancer that is hard to control against.
- DenisM 8y ago
  Monochromatic red light in the bathroom should take care of placebo problem? Or red glasses, something like that. Maybe artificial piss color.

delbel 8y ago

thanks for your post. That would be funny if the cure is to drink the "Methylene Blue Kool Aid"

tcj_phx 8y ago

Methylene blue is also an monoamine oxidase inhibitor. I add it to my dog’s food to boost her metabolism. She blew her knee out a year ago (common injury for large 10yo dogs) but has mostly recovered without the surgery the vet said she’d probably need. (I use a variety of interventions with her.) Methylene blue should not be combined with the later anti-depressants that focus more on serotonin (SSRIs, etc.), as this can cause serotonin toxicity: https://www.apsf.org/article/methylene-blue-and-the-risk-of-serotonin-toxicity/ https://www.apsf.org/article/methylene-blue-and-the-risk-of-... > Tau is working on a slightly modified form that is basically putting it in a capsule and they'll sell it for $50 a pill probably, but that's the only way that anyone will believe it actually works. Patent medicines [1] are still as popular as they ever were. Science made some inroads in the early 20th century, before the hucksters regrouped, with new prescription-only FDA approved nostrums. [1] https://en.m.wikipedia.org/wiki/Patent_medicine https://en.m.wikipedia.org/wiki/Patent_medicine

mrtnmcc 8y ago

Other studies of mild to moderate Alzheimer's patients showed no improvement with Methylene blue, https://www.alzforum.org/news/conference-coverage/first-phase-3-trial-tau-drug-lmtm-did-not-work-period https://www.alzforum.org/news/conference-coverage/first-phas... Also I'd generally be more skeptical as the green urine it produces could be a strong placebo enhancer that is hard to control against.

DenisM 8y ago
Monochromatic red light in the bathroom should take care of placebo problem? Or red glasses, something like that. Maybe artificial piss color.