Sure, I usually set org files up by book/talk > chapter/concept > (any further level of nesting)+. Here are a couple examples. From watching "Abstract" on Netfl

Sure, I usually set org files up by book/talk > chapter/concept > (any further level of nesting)+. Here are a couple examples. From watching "Abstract" on Netflix I did one entry for the show with a bunch of random notes because there wasn't as much structure to the content. Most of my book notes more or less follow the book > chapter > sub heading pattern. Tech talks usually have a format like talk title > subject > details. I've stuck to using one file for most of my notes the last few years. You should play around with it and see what works best for you. Reading with a desktop or laptop has been easier for me since it's more familiar. I'm not really a fan of mobile phones or kindle readers. Evince or fbreader work OK on linux. You could add espeak or another TTS tool for speaking text. On OSX there's acrobat with voice over. Screen readers exist but are harder to control. The tools for reading via TTS are pretty primitive right now unfortunately. I'm pretty bad at syncing notes... I've primarily done it with rsync over ssh. If you save things back to a server and sync from there that could work. Otherwise there's easier stuff like Google Drive or Dropbox.