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Try it once. The salient point about drugs like ecstasy is that they don’t actually add to the chemicals to your brain that make you feel good - instead they re

Try it once. The salient point about drugs like ecstasy is that they don’t actually add to the chemicals to your brain that make you feel good - instead they release the reserves in your brain all at once. Those incredible highs are all of your nice feelings for the next couple weeks getting released at once. It’s a trade off I don’t want to make.

SirensOfTitan 8y ago
> Those incredible highs are all of your nice feelings for the next couple weeks getting released at once. This is a massive simplification. It represents the pop-psych nonsense like serotonin is the happiness molecule. It really depends. Mood and brain chemistry are much more complex than: serotonin, dopamine, acetylcholine, norepinephrine My anecdata: most of my friends have a down day 1-2 days after, then they’re fine. A couple have a really hard down day, others don’t have comedowns. This comment is irresponsible in that it confuses anecdote for data and uses a very inaccurate metaphor. Good advice here is: if you want to try MDMA: 1. Test your product. Almost none of the MDMA on the streets is actually MDMA. It’s usually bath salts or something else unsavory 2. Dose correctly. MDMA is dosed generally based on body weight. If you don’t have the luxury of weighing you should probably take 75mg to 100mg. 3. Spend some time during your experience grappling with things that have bothered you lately. This is purely anecdotal, but this helps me with both the comedown and helps me figure out difficult things I’ve recently had difficulty with. 4. Expect some sad feelings 1-2 days after, so if you can plan those days around close friends in non stressful environments.
- cc81 8y ago
  >Almost none of the MDMA on the streets is actually MDMA. That is not really true. At least not in Europe. Real MDMA is incredibly common.
  - SirensOfTitan 8y ago
    I have read that Europe has less fake MDMA, but regardless everyone should be testing. From rollsafe.org: > 87% of “Molly” analyzed by the DEA between 2009 and 2013 contained 0% MDMA, instead mostly containing “bath salts.” > 46% of Ecstasy tablets analyzed in a study contained 0% MDMA.
    - cr1895 8y ago
      That’s interesting...almost the opposite result was found by the Dutch drugs monitoring institute, with over 90% of analyzed pills containing MDMA. https://energycontrol-international.org/wp-content/uploads/2016/04/Drug-Testing-in-Europe-Monitoring-Results.pdf https://energycontrol-international.org/wp-content/uploads/2...
  - okmokmz 8y ago
    By and large, most of the "ecstasy"/"MDMA" sold at the street level is a mix of cheap research chemicals and amphetamines. I volunteered at a tent that tested drugs at festivals, and for every 10 people that thought they had pure MDMA maybe 1-2 in 10 tested positive for containing any MDMA
    - ryanmarsh 8y ago
      That's one way to get people to be more skeptical of the psychotropic substances they're taking. Wish kits like this were wide spread.
    - cr1895 8y ago
      This is not universally true, at least it is certainly false in the Netherlands. https://energycontrol-international.org/wp-content/uploads/2016/04/Drug-Testing-in-Europe-Monitoring-Results.pdf https://energycontrol-international.org/wp-content/uploads/2... See figure 7.
    - sxv 8y ago
      Very interesting. Did you publish any data or do you have any references you could share?
- ridewinter 8y ago
  A massive simplification - sounds like a compliment. Perhaps people need the complexities of brain chemistry simplified to understand what they’re getting into. The important thing is that all of those chemicals you described get released at once, and while you may only notice the acute effects for a couple days, the subtle effects last a lot longer. To massively simplify again - a week later maybe you can’t enjoy a sunset as much as you normally do, whether you’re cogniscent of it or not.
  - taurath 8y ago
    To massively simplify, you are focused entirely on the negative effects which can be mitigated especially in a clinical setting. What you're describing as a "bad" thing is that all the chemicals get released at once - what that does is create the perfect mental environment to deal with issues or trauma that would be literally too painful to access otherwise. Often times the benefit of getting through or starting a journey of healing of some long-standing problem will hugely outweigh the minor downregulation of neurochemicals afterwards (you will feel a little slow).
    - ridewinter 8y ago
      If I thought the side effects could be mitigated I’d be doing it all the time ;) But I’m skeptical and don’t buy into all of those downplaying the effects as “minor”.
      - taurath 8y ago
        The mechanism still depletes your stores of neurotransmitters, but the neurotoxic effects and the "regrowth" period can be mitigated with supplements. Nobody should do it more often than once every 2 weeks under any circumstances, and only then in a clinical setting - once ever 2-3 months is okayish, but again the more environmental control the better.
bagacrap 8y ago
This is not my experience. If you overdo it, this can happen, but with the proper dosage there is no noticeable happiness hangover.

SirensOfTitan 8y ago

> Those incredible highs are all of your nice feelings for the next couple weeks getting released at once. This is a massive simplification. It represents the pop-psych nonsense like serotonin is the happiness molecule. It really depends. Mood and brain chemistry are much more complex than: serotonin, dopamine, acetylcholine, norepinephrine My anecdata: most of my friends have a down day 1-2 days after, then they’re fine. A couple have a really hard down day, others don’t have comedowns. This comment is irresponsible in that it confuses anecdote for data and uses a very inaccurate metaphor. Good advice here is: if you want to try MDMA: 1. Test your product. Almost none of the MDMA on the streets is actually MDMA. It’s usually bath salts or something else unsavory 2. Dose correctly. MDMA is dosed generally based on body weight. If you don’t have the luxury of weighing you should probably take 75mg to 100mg. 3. Spend some time during your experience grappling with things that have bothered you lately. This is purely anecdotal, but this helps me with both the comedown and helps me figure out difficult things I’ve recently had difficulty with. 4. Expect some sad feelings 1-2 days after, so if you can plan those days around close friends in non stressful environments.

cc81 8y ago
>Almost none of the MDMA on the streets is actually MDMA. That is not really true. At least not in Europe. Real MDMA is incredibly common.
- SirensOfTitan 8y ago
  I have read that Europe has less fake MDMA, but regardless everyone should be testing. From rollsafe.org: > 87% of “Molly” analyzed by the DEA between 2009 and 2013 contained 0% MDMA, instead mostly containing “bath salts.” > 46% of Ecstasy tablets analyzed in a study contained 0% MDMA.
  - cr1895 8y ago
    That’s interesting...almost the opposite result was found by the Dutch drugs monitoring institute, with over 90% of analyzed pills containing MDMA. https://energycontrol-international.org/wp-content/uploads/2016/04/Drug-Testing-in-Europe-Monitoring-Results.pdf https://energycontrol-international.org/wp-content/uploads/2...
- okmokmz 8y ago
  By and large, most of the "ecstasy"/"MDMA" sold at the street level is a mix of cheap research chemicals and amphetamines. I volunteered at a tent that tested drugs at festivals, and for every 10 people that thought they had pure MDMA maybe 1-2 in 10 tested positive for containing any MDMA
  - ryanmarsh 8y ago
    That's one way to get people to be more skeptical of the psychotropic substances they're taking. Wish kits like this were wide spread.
  - cr1895 8y ago
    This is not universally true, at least it is certainly false in the Netherlands. https://energycontrol-international.org/wp-content/uploads/2016/04/Drug-Testing-in-Europe-Monitoring-Results.pdf https://energycontrol-international.org/wp-content/uploads/2... See figure 7.
  - sxv 8y ago
    Very interesting. Did you publish any data or do you have any references you could share?
ridewinter 8y ago
A massive simplification - sounds like a compliment. Perhaps people need the complexities of brain chemistry simplified to understand what they’re getting into. The important thing is that all of those chemicals you described get released at once, and while you may only notice the acute effects for a couple days, the subtle effects last a lot longer. To massively simplify again - a week later maybe you can’t enjoy a sunset as much as you normally do, whether you’re cogniscent of it or not.
- taurath 8y ago
  To massively simplify, you are focused entirely on the negative effects which can be mitigated especially in a clinical setting. What you're describing as a "bad" thing is that all the chemicals get released at once - what that does is create the perfect mental environment to deal with issues or trauma that would be literally too painful to access otherwise. Often times the benefit of getting through or starting a journey of healing of some long-standing problem will hugely outweigh the minor downregulation of neurochemicals afterwards (you will feel a little slow).
  - ridewinter 8y ago
    If I thought the side effects could be mitigated I’d be doing it all the time ;) But I’m skeptical and don’t buy into all of those downplaying the effects as “minor”.
    - taurath 8y ago
      The mechanism still depletes your stores of neurotransmitters, but the neurotoxic effects and the "regrowth" period can be mitigated with supplements. Nobody should do it more often than once every 2 weeks under any circumstances, and only then in a clinical setting - once ever 2-3 months is okayish, but again the more environmental control the better.

bagacrap 8y ago

This is not my experience. If you overdo it, this can happen, but with the proper dosage there is no noticeable happiness hangover.