4 ms·

Agreed! Been a long time since I experimented with drugs, but when I used to, pure MDMA was really great. Just puts you in a super positive frame of mind, and m

by yashap 8y ago

Agreed! Been a long time since I experimented with drugs, but when I used to, pure MDMA was really great. Just puts you in a super positive frame of mind, and makes you feel incredibly close and connected to whoever you’re doing it with. Not surprised at all that there’s a lot of therapeutic potential there.

simonsaidit 8y ago
Yes but it’s also pretty common to get into this regularly and soon after what you get one evening you have to give back some weeks later unless you then take all sorts of other drugs to compensate for that. I’ve seen the therapeutic effects up close and they are powerful but they are sadly short lived and hard to manage.
- meowface 8y ago
  All advice I've seen regarding the substance is to not take it more than once every 3 months. I think people just need to realize it really isn't a party drug you can take every or every other weekend. Not only will tolerance build very rapidly, but you're exposing your brain to excessive oxidative stress and overheating, and are likely causing serotonergic neurotoxicity (even if you take it with all the recommended supplements). It needs to be treated like a rare, therapeutic, and special vacation, not something you take whenever you want to have fun.
  - simonsaidit 8y ago
    yup. but young people in a culture where its quite common to do this every weekend are in a big risk not to follow that advice though.
- yahyaheee 8y ago
  The MAPS studies tell a different story here, only a couple sessions and over a year later a large majority of the subjects were still symptom free or greatly reduced
  - simonsaidit 8y ago
    My personal studies tell Otherwise... and those studies probably doesnt consider how easy it is to self medicate and get the oppersite effect. It Works Well but its a temp fix and its hard to handle yourself Especially if you are Young abd part of a culture that uses this recretional.
    - stickfigure 8y ago
      Where have you published your studies?
      - simonsaidit 8y ago
        They are personal ;) luckily I now don’t take everything I read for truth and had the guts to look at the risk/benefit in person. Few who ever did studies had any real exposure to what they write about or have the insight to get near the relevant data to make a proper study. First hand experience beats that anyday and having seen more than most I can not recommend any recreational drugs perhaps more that once but keeping it to that is insanely difficult so I’d say you have to be in a specific pet if your life to even try. By I regard Changa as medicine that few would ever use recreational but it’s also not for everyone.
- yashap 8y ago
  Yeah, all drugs can have big negative impacts on people’s lives if not taken in moderation. This is true of legal recreational drugs like alcohol, and pharmaceuticals like opioid painkillers. But most people use these drugs responsibly. I think if MDMA really does work great for PTSD in therapeutic settings, it’d be a worthwhile treatment, even though some percentage of patients would abuse it.
Fnoord 8y ago
What about the rebound effect ("tuesday dip")?
- simonsaidit 8y ago
  Exactly. :)
- senorjazz 8y ago
  from what I understand, in a medical setting, those treated with MDMA are not / have not been regular users. New recreational users very often do not get a prolonged comedown / tuesday blues / suicide wednesday. Which is more indicative of heavier user, multiple doses, staying up all night, taking over drugs (including alcohol). In a controlled setting, with a correct one time dose, in a clinical environment, not running around like a loon, sleeping and eating well, in one off sessions, the mid week comedown can be mitagated away
- cryoshon 8y ago
  i didn't experience this. the next day, i was mostly just tired from not having slept. then again, it was a one-off thing. might be harder for regular users.
- yashap 8y ago
  As senorjazz mentioned, I wonder how much of the really bad recoveries are due to taking too much, mixing it with other drugs, staying up super late, etc? I only did it a handful of times, a long time ago, but if I took a reasonable amount and just had a chill night on the beach with friends, the recovery wasn’t so bad. One day of feeling tired/down, but similar intensity to a moderate hangover.
  - Fnoord 8y ago
    MDMA, when I used it, was always combined with dancing or walking or physical activity. I also always had a coming down which had a bottom peak a few days after (the infamous Tuesday dip). With psilocybin I had not much of a coming down, at worst a headache the day after. With MDMA though, the coming down additionally had my mood being down as well. I become agitated and inward, very much in contrast to the peak and moderate upper effect (there are some movies which portrait this, such as the movie Human Traffic [1]). Then again, this is anecdotal, and I am very sensitive to drugs in general, especially the contrasts (alcohol, beer makes me often tired, MDMA, SSRIs, amphetamine). The reason for that might very well be related to ASD, I do not know for sure though. I just know that I do have ASD. But because I have ASD, my anecdotal experience isn't typical in this case. However the Tuesday dip is widely known among MDMA users. [1] https://en.wikipedia.org/wiki/Human_Traffic https://en.wikipedia.org/wiki/Human_Traffic

by yashap 8y ago

simonsaidit 8y ago

Yes but it’s also pretty common to get into this regularly and soon after what you get one evening you have to give back some weeks later unless you then take all sorts of other drugs to compensate for that. I’ve seen the therapeutic effects up close and they are powerful but they are sadly short lived and hard to manage.

meowface 8y ago
All advice I've seen regarding the substance is to not take it more than once every 3 months. I think people just need to realize it really isn't a party drug you can take every or every other weekend. Not only will tolerance build very rapidly, but you're exposing your brain to excessive oxidative stress and overheating, and are likely causing serotonergic neurotoxicity (even if you take it with all the recommended supplements). It needs to be treated like a rare, therapeutic, and special vacation, not something you take whenever you want to have fun.
- simonsaidit 8y ago
  yup. but young people in a culture where its quite common to do this every weekend are in a big risk not to follow that advice though.
yahyaheee 8y ago
The MAPS studies tell a different story here, only a couple sessions and over a year later a large majority of the subjects were still symptom free or greatly reduced
- simonsaidit 8y ago
  My personal studies tell Otherwise... and those studies probably doesnt consider how easy it is to self medicate and get the oppersite effect. It Works Well but its a temp fix and its hard to handle yourself Especially if you are Young abd part of a culture that uses this recretional.
  - stickfigure 8y ago
    Where have you published your studies?
    - simonsaidit 8y ago
      They are personal ;) luckily I now don’t take everything I read for truth and had the guts to look at the risk/benefit in person. Few who ever did studies had any real exposure to what they write about or have the insight to get near the relevant data to make a proper study. First hand experience beats that anyday and having seen more than most I can not recommend any recreational drugs perhaps more that once but keeping it to that is insanely difficult so I’d say you have to be in a specific pet if your life to even try. By I regard Changa as medicine that few would ever use recreational but it’s also not for everyone.
yashap 8y ago
Yeah, all drugs can have big negative impacts on people’s lives if not taken in moderation. This is true of legal recreational drugs like alcohol, and pharmaceuticals like opioid painkillers. But most people use these drugs responsibly. I think if MDMA really does work great for PTSD in therapeutic settings, it’d be a worthwhile treatment, even though some percentage of patients would abuse it.

Fnoord 8y ago

What about the rebound effect ("tuesday dip")?

simonsaidit 8y ago
Exactly. :)
senorjazz 8y ago
from what I understand, in a medical setting, those treated with MDMA are not / have not been regular users. New recreational users very often do not get a prolonged comedown / tuesday blues / suicide wednesday. Which is more indicative of heavier user, multiple doses, staying up all night, taking over drugs (including alcohol). In a controlled setting, with a correct one time dose, in a clinical environment, not running around like a loon, sleeping and eating well, in one off sessions, the mid week comedown can be mitagated away
cryoshon 8y ago
i didn't experience this. the next day, i was mostly just tired from not having slept. then again, it was a one-off thing. might be harder for regular users.
yashap 8y ago
As senorjazz mentioned, I wonder how much of the really bad recoveries are due to taking too much, mixing it with other drugs, staying up super late, etc? I only did it a handful of times, a long time ago, but if I took a reasonable amount and just had a chill night on the beach with friends, the recovery wasn’t so bad. One day of feeling tired/down, but similar intensity to a moderate hangover.
- Fnoord 8y ago
  MDMA, when I used it, was always combined with dancing or walking or physical activity. I also always had a coming down which had a bottom peak a few days after (the infamous Tuesday dip). With psilocybin I had not much of a coming down, at worst a headache the day after. With MDMA though, the coming down additionally had my mood being down as well. I become agitated and inward, very much in contrast to the peak and moderate upper effect (there are some movies which portrait this, such as the movie Human Traffic [1]). Then again, this is anecdotal, and I am very sensitive to drugs in general, especially the contrasts (alcohol, beer makes me often tired, MDMA, SSRIs, amphetamine). The reason for that might very well be related to ASD, I do not know for sure though. I just know that I do have ASD. But because I have ASD, my anecdotal experience isn't typical in this case. However the Tuesday dip is widely known among MDMA users. [1] https://en.wikipedia.org/wiki/Human_Traffic https://en.wikipedia.org/wiki/Human_Traffic