This was a study that caught my attention recently: https://jamanetwork.com/journals/jamasurgery/article-abstract/2689031 https://jamanetwork.com/journals/jama

This was a study that caught my attention recently: https://jamanetwork.com/journals/jamasurgery/article-abstract/2689031 https://jamanetwork.com/journals/jamasurgery/article-abstrac... Cipro greatly increased the rate of aortic aneurysm/dissection in mice when they were challenged with high blood pressure. The examination goes into detail about the reasons. Essentially the drug both inhibits connective tissue repair and starts degrading it. So the black box warning is about tendons, but there's connective tissue all over the body (like in the aorta). There's probably a subset of individuals more genetically susceptible to the disruption, but it looks like this could worsen lots of latent issues in just about anyone.