Yes, definitely. Only the GUI for Jupiter is in the browser — the computation is on a workstation, server, or an iPython parallel cluster, so you can use proper

Yes, definitely. Only the GUI for Jupiter is in the browser — the computation is on a workstation, server, or an iPython parallel cluster, so you can use proper HPC resources. Another common pattern (because socket-based communication can die) is to run the heavy HPC stuff with SLURM, etc. then compile and analyze the results in the notebook.