> Thus, the pre-filter would find a good fit against the reference copy, compute a diff that's sparse, and compress that. Yeah that already happens [1]. But be

> Thus, the pre-filter would find a good fit against the reference copy, compute a diff that's sparse, and compress that. Yeah that already happens [1]. But before you can compute the diff, you have to read the genome with a level of confidence, which generates a lot of data. [1] https://en.wikipedia.org/wiki/Variant_Call_Format https://en.wikipedia.org/wiki/Variant_Call_Format