If the Python module was large and complex, it does something that would be incredibly difficult to replicate in nodejs either given the current ecosystem or co

If the Python module was large and complex, it does something that would be incredibly difficult to replicate in nodejs either given the current ecosystem or costs of a rewrite, is not available in Rust/C/C++ that could be WASM'd (not mentioning others here due to large WASM overhead), you accept the large binary sizes of these things (i.e. you're not embedding the Python interpreter/runtime and putting on npm), and you're willing to put a node-friendly layer on top that makes the lower level calls...then it might be sane. But I'd consider modernizing to an updated emscripten that does WASM, see if you can avoid some emscripten runtime (i.e. WASM standalone compilation). For all other cases, stay in Node or use a lib from a language more suited to WASM compilation. Now, if it's an option between this and a native Node module, that depends on your opinion of Node FFI and native Node modules.