It's also the most statistically significant gene, in the whole dang genome, associated with Type 2 Diabetes. And out of a compound library of 20k chemicals, B

It's also the most statistically significant gene, in the whole dang genome, associated with Type 2 Diabetes. And out of a compound library of 20k chemicals, BPA had the top effect on it. Seems significant to me Also worth noting that BPA has been shown to specifically effect the occupancy of TCF7L2 at transcription factor binding sites in Chip-Seq experiments. http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2015.ED.1.FRI-299 http://press.endocrine.org/doi/abs/10.1210/endo-meetings.201... Lastly, before calling someone else's claims psuedoscientific, you may want to do some homework and check your previous biases. We could certainly use someone with your skills to help model BPAs interaction with the Androgen receptor. Might just save millions of lives....