3 ms·

There's a notable lack of dose-response relationship in most of the collected data, and n=12 for each group doesn't inspire confidence even if in some cases the

There's a notable lack of dose-response relationship in most of the collected data, and n=12 for each group doesn't inspire confidence even if in some cases the p-value suggests significance. There are already a lot of measurements taken and included in the table where differences were not that large. Were other measurements taken and not reported in the table? Has anyone attempted to reproduce this? Most importantly, though, that study doesn't indicate whether the effects, if they end up being reproducible, are caused by BPA alone, or the combination of BPA+sugar. It's well known in other scenarios that toxins, when combined with inflammatory foods like sugar, are far worse than they are in the absence of inflammatory foods. I'm fairly convinced that BPA is slightly bad, I just think alternative plastics may turn out to have other compounds that are also bad, given horrible diets, and the best solution may be to fix the diet, rather than try to eliminate all toxins related to modern plastics (and the same argument may apply to pesticides). Other toxins from modern living will undoubtedly pop up, and if they all cause different and problematic diseases in combination with bad diets, but not so much in combination with good diets, how much energy do we really need to put into studying and eliminating toxins in a giant game of whack-a-mole?

subcosmos 8y ago
I havent yet seen other studies comparing BPA with carb ingestion, but I hope they are done. Its important to root out the effect since BPA lines every single soda-pop can. Aside from that though, there are many other mouse studies. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2605.2007.00832.x https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2605.... As well as studies showing that BPA in human urine is associated with insulin resistance and obesity https://academic.oup.com/jcem/article/97/2/E223/2836542 https://academic.oup.com/jcem/article/97/2/E223/2836542
subcosmos 8y ago
Note that this study specifically showed that fructose alone did not increase liver fat content unless BPA was present in the solution. See figure 3, but yes, I agree that it would have been nice if they tried BPA without the fructose. This really does make sense. When that pathway is suppressed, the adipogenic program is activated, which turns on the SREBP-1 pathway and stores lipid droplets. Without this pathway activated, fructose is processed and exported out of the liver, preventing harm to the liver. I would argue that we should really test every new manmade chemical against a library of our proteins before we synthesize anything new and introduce millions of tons of it to the world. Not doing so can have disasterous consequences. Samuel Epstein, before he died, documented a great many examples of horror stories we just barely averted. https://www.youtube.com/watch?v=rQoc6WP3QJo https://www.youtube.com/watch?v=rQoc6WP3QJo

subcosmos 8y ago

I havent yet seen other studies comparing BPA with carb ingestion, but I hope they are done. Its important to root out the effect since BPA lines every single soda-pop can. Aside from that though, there are many other mouse studies. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2605.2007.00832.x https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2605.... As well as studies showing that BPA in human urine is associated with insulin resistance and obesity https://academic.oup.com/jcem/article/97/2/E223/2836542 https://academic.oup.com/jcem/article/97/2/E223/2836542

subcosmos 8y ago

Note that this study specifically showed that fructose alone did not increase liver fat content unless BPA was present in the solution. See figure 3, but yes, I agree that it would have been nice if they tried BPA without the fructose. This really does make sense. When that pathway is suppressed, the adipogenic program is activated, which turns on the SREBP-1 pathway and stores lipid droplets. Without this pathway activated, fructose is processed and exported out of the liver, preventing harm to the liver. I would argue that we should really test every new manmade chemical against a library of our proteins before we synthesize anything new and introduce millions of tons of it to the world. Not doing so can have disasterous consequences. Samuel Epstein, before he died, documented a great many examples of horror stories we just barely averted. https://www.youtube.com/watch?v=rQoc6WP3QJo https://www.youtube.com/watch?v=rQoc6WP3QJo