3 ms·

> We can keep running on the macronutrient treadmill, People reach obesity from overeating, no matter what their choice of calorie-dense foods, but it's typica

> We can keep running on the macronutrient treadmill, People reach obesity from overeating, no matter what their choice of calorie-dense foods, but it's typically sugar or fats, and sugar is the cheapest/most available. Being obese is clearly a causative factor towards T2B [1]. How are these obvious truths 'running on a treadmill'? [1] https://www.diabetes.co.uk/diabetes-and-obesity.html https://www.diabetes.co.uk/diabetes-and-obesity.html

subcosmos 8y ago
The treadmill is the endless debate over whether or not fats vs carbs are more obesogenic. This debate continues ad-nauseum and distracts from more nuanced explanations. High fat consumption raises inflammatory profiles through mechanisms that are poorly understood. Carbohydrates seem to cause similar inflammation, but this is largely do to advanced gylcation end-products created from fructose, specifically. Overeating is not interesting. The reason people do overeat is very interesting, and if you hit the literature you find that this is largely driven by damage to the hypothalamus by environmental exposure.
- allover 8y ago
  > Overeating is not interesting. The reason people do overeat is very interesting What if it's not. What if people just overeat because life is boring, and food tastes good, and we all have differing levels of willpower & education on nutrition? > if you hit the literature you find that this is largely driven by damage to the hypothalamus by environmental exposure. Sounds like nonsense, can you elaborate?
  - subcosmos 8y ago
    There is a specific part of the hypothalamus called the arcuate nucleus. It lacks a blood brain barrier, because the neurons there have a special function to sense blood-born hormones like insulin and leptin. When sensed, the brain interprets this as a "full tank of gas" and suppresses appetite while increasing metabolism. Since theres no blood brain barrier here, these neurons get damaged easily due to things in the blood. When that happens, they don't see leptin anymore, and obesity develops. Fructose and high fat diets have both been shown to cause inflammation here. (hypothalamic gliosis) heres a random selection of many papers http://diabetes.diabetesjournals.org/content/65/3/551.figures-only http://diabetes.diabetesjournals.org/content/65/3/551.figure... We also know that certain viruses show up in obese people (adenovirus36). As the field develops, I would not be surprised if labs demonstrate both viral infection of the hypothalamic ARC and damage by endocrine disruptors there.
  - amanaplanacanal 8y ago
    > What if it's not. What if people just overeat because life is boring, and food tastes good, and we all have differing levels of willpower & education on nutrition? Then we need to explain why this suddenly became a problem in the 1970s. Life is more boring now? We all lost our willpower? People understood nutrition better before that? Something has changed, either in humanity or the environment. My bet is the environment.
    - ragazzina 8y ago
      Was there enough extremely cheap and tasty food before the 1970s?

subcosmos 8y ago

The treadmill is the endless debate over whether or not fats vs carbs are more obesogenic. This debate continues ad-nauseum and distracts from more nuanced explanations. High fat consumption raises inflammatory profiles through mechanisms that are poorly understood. Carbohydrates seem to cause similar inflammation, but this is largely do to advanced gylcation end-products created from fructose, specifically. Overeating is not interesting. The reason people do overeat is very interesting, and if you hit the literature you find that this is largely driven by damage to the hypothalamus by environmental exposure.

allover 8y ago
> Overeating is not interesting. The reason people do overeat is very interesting What if it's not. What if people just overeat because life is boring, and food tastes good, and we all have differing levels of willpower & education on nutrition? > if you hit the literature you find that this is largely driven by damage to the hypothalamus by environmental exposure. Sounds like nonsense, can you elaborate?
- subcosmos 8y ago
  There is a specific part of the hypothalamus called the arcuate nucleus. It lacks a blood brain barrier, because the neurons there have a special function to sense blood-born hormones like insulin and leptin. When sensed, the brain interprets this as a "full tank of gas" and suppresses appetite while increasing metabolism. Since theres no blood brain barrier here, these neurons get damaged easily due to things in the blood. When that happens, they don't see leptin anymore, and obesity develops. Fructose and high fat diets have both been shown to cause inflammation here. (hypothalamic gliosis) heres a random selection of many papers http://diabetes.diabetesjournals.org/content/65/3/551.figures-only http://diabetes.diabetesjournals.org/content/65/3/551.figure... We also know that certain viruses show up in obese people (adenovirus36). As the field develops, I would not be surprised if labs demonstrate both viral infection of the hypothalamic ARC and damage by endocrine disruptors there.
- amanaplanacanal 8y ago
  > What if it's not. What if people just overeat because life is boring, and food tastes good, and we all have differing levels of willpower & education on nutrition? Then we need to explain why this suddenly became a problem in the 1970s. Life is more boring now? We all lost our willpower? People understood nutrition better before that? Something has changed, either in humanity or the environment. My bet is the environment.
  - ragazzina 8y ago
    Was there enough extremely cheap and tasty food before the 1970s?