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I never said it was a bad analogy, I even used a rather positive word ('seductive'). It is overrated, though, and it does stop making sense sooner than many peo
by aluren 8y ago
I never said it was a bad analogy, I even used a rather positive word ('seductive'). It is overrated, though, and it does stop making sense sooner than many people think. What I'm really saying is that relying on this analogy to understand how DNA works in relation to organism development, function, etc. won't get you past a very cursory understanding of it. It may be enough for many people but:
-I like to think that HN is filled with people who take interest in many things, especially science-related subjects, and would hope that many of them on this site would like to know more than an analogy-based understanding of genomics
-For better or for worse, the recent bloom and advances in genetics and biology in general have taken over the modern world and been hailed (probably with reason) by all kinds of circles, from the media to governments or the tech world, as a promising new era that's going to revolutionize our understanding of life, disease, what it means to be human, cognition, what have you. It does feel pretty cool as an insider to know that you're working in the 'hot new thing' but a side effect of that is, I have seen people develop a pretty bizarre fascination with DNA, whether it be their own or other people's. And it's not something that can be pinpointed to entirely rational reasons. I don't want to go off tangents any further, but let's say it can't hurt to occasionnally remind people what DNA is and what it isn't, what it's like and what it's definitely not like. I dislike pedants as much as the next person but seeing so many (presumably very educated) people take that analogy in the same thread made me think that the reminder wasn't that out of place.
- rubatuga 8y agoI disagree, DNA is pretty much the source code. any differential DNA expression are due to histone modification, proteins, or RNA (and rarely CpG DNA modification in humans) so DNA in the purest form is indeed the source code.
- aluren 8y agoSource code for what, though? How about pre-natal influences in the womb, does this mean the womb is a sort of compiler? What about the structure of DNA itself, known to influence gene expression levels? What about the microbiota, which is arguably more 'you' than your own body in terms of raw cell count? What about the phages found in the microbiota (the phageome)? Why are they not part of the so-called source code?
- rubatuga 8y agoSource code/machine code, I am just interchanging but in this analogy they are equivalent. Pre-natal influences change the epigenetics, i.e. "on" the genome. The structure of DNA is almost completely determined by histones, which are proteins that DNA wrap around, so once again, not the DNA. Microbiota affect the environment of the cells, meaning it is an input to the cell, not the source code. Any phages affecting the microbiota will affect the input to the cell. These factors aren't considered source code simply because it only affects the execution of the cell's source code.
- toasterlovin 8y agoThe source code for the organism.