Is it possible that glioblastoma cancer is a result of two different dysfunctions? The glioblastoma tumor in the brain, and an unrelated sequestration of T cel

Is it possible that glioblastoma cancer is a result of two different dysfunctions? The glioblastoma tumor in the brain, and an unrelated sequestration of T cells in the bone marrow? The abstract states that the loss of S1P1 is tumor imposed, but not having access to the paper, I don't know what they mean by that.