3 ms·

>"The mechanism by which a tumor suppresses and evades immune response is tremendously complex." What is so complex about it? >"Every type of response for eve

by nonbel 8y ago

>"The mechanism by which a tumor suppresses and evades immune response is tremendously complex." What is so complex about it? >"Every type of response for every category of tumor cell must be decoded. As well as every effective ligand to boost immune cell strategy." Why? Also, the "categories of tumor cell" are arbitrary. The categories are chosen by humans for ease of communication and understanding. You can have as many or as few as you want.

HeadsUpHigh 8y ago
Think hundreds if not more different pathways utilizing many different mechanisms that are not even mapped that well. Anything from external to the cell molecules to internal ones to noise based ones. And then add on top of that variations in tumor topography and variations in each tumor type that make some people with the same cancer react to a drug really well while others don't. Also no categorization in medicine is arbitrary ( or at least almost none). Everything on a clinical level is categorized based either on how it's best diagnosed or cured, for example a cancer might be categorized as a small cell lung cancer when it comes to chemo but use a different classification scheme from radiologists when surgeons are concerned because they care about the area of effect instead ( in both cases a cure based taxonomy). The small cell cancer has different molecular signatures than e.g. non small cell types which means it will react differently on specialized antibody therapies. This taxonomy is nowadays expanding rapidly based on new drugs and studies on which variations of proteins they are effective.
- nonbel 8y ago
  >"Think hundreds if not more different pathways utilizing many different mechanisms that are not even mapped that well." Perhaps "pathways" isn't the right way to think about whats going on if it makes it seem so complex.
  - HeadsUpHigh 8y ago
    Pathway is the official them used
- nonbel 8y ago
  >"Also no categorization in medicine is arbitrary ( or at least almost none)." Ok, this is crackpot.

by nonbel 8y ago

HeadsUpHigh 8y ago

Think hundreds if not more different pathways utilizing many different mechanisms that are not even mapped that well. Anything from external to the cell molecules to internal ones to noise based ones. And then add on top of that variations in tumor topography and variations in each tumor type that make some people with the same cancer react to a drug really well while others don't. Also no categorization in medicine is arbitrary ( or at least almost none). Everything on a clinical level is categorized based either on how it's best diagnosed or cured, for example a cancer might be categorized as a small cell lung cancer when it comes to chemo but use a different classification scheme from radiologists when surgeons are concerned because they care about the area of effect instead ( in both cases a cure based taxonomy). The small cell cancer has different molecular signatures than e.g. non small cell types which means it will react differently on specialized antibody therapies. This taxonomy is nowadays expanding rapidly based on new drugs and studies on which variations of proteins they are effective.

nonbel 8y ago
>"Think hundreds if not more different pathways utilizing many different mechanisms that are not even mapped that well." Perhaps "pathways" isn't the right way to think about whats going on if it makes it seem so complex.
- HeadsUpHigh 8y ago
  Pathway is the official them used
nonbel 8y ago
>"Also no categorization in medicine is arbitrary ( or at least almost none)." Ok, this is crackpot.