3 ms·

That theory would seem to contradict the study I cited, no? Both papers you cite are by the same group, and I don't think the results represent a consensus of

That theory would seem to contradict the study I cited, no? Both papers you cite are by the same group, and I don't think the results represent a consensus of the experts.

vanderZwan 8y ago
Not necessarily: in another study it was shown that kynurenine levels went back to original levels in patients who only exercised[0]. > Conclusions: Physical exercise positively affects mood and cardiovascular fitness, but does not lead to long-lasting changes in plasma levels of kynurenine and KYNA in patients affected by mild-to-moderate depression. So that would suggest that the body just reaches a new equilibrium. Again, the point is that resilience does not fix causes - it could be that this is similar to trying to fix traffic jams with more roads; the only real fix is to get rid of the cars as much as you can (after which having an extra lane can make traffic go smoother). > Both papers you cite are by the same group, and I don't think the results represent a consensus of the experts. IIRC, that kynurenine does something is apparently well-established, and not just by this group. Also, that first paper has quite a few citations, you can check for follow-up research on Google Scholar[1] [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384718/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384718/ [1] https://scholar.google.de/scholar?hl=en&as_sdt=0%2C5&q=Skeletal+Muscle+PGC-1%CE%B11+Modulates+Kynurenine+Metabolism+and+Mediates+Resilience+to+Stress-Induced+Depression&btnG= https://scholar.google.de/scholar?hl=en&as_sdt=0%2C5&q=Skele...
- jessriedel 8y ago
  > So that would suggest that the body just reaches a new equilibrium. This is another degree of freedom in the theory, right? I mean, this could all be true for all I know, but as an outsider I think this falls into the category of stuff I can't judge, and (like a thousand other theories investigated by experts and published in impressive places like Science) hasn't yet risen to the level of consensus.

That theory would seem to contradict the study I cited, no? Both papers you cite are by the same group, and I don't think the results represent a consensus of the experts.

vanderZwan 8y ago

Not necessarily: in another study it was shown that kynurenine levels went back to original levels in patients who only exercised[0]. > Conclusions: Physical exercise positively affects mood and cardiovascular fitness, but does not lead to long-lasting changes in plasma levels of kynurenine and KYNA in patients affected by mild-to-moderate depression. So that would suggest that the body just reaches a new equilibrium. Again, the point is that resilience does not fix causes - it could be that this is similar to trying to fix traffic jams with more roads; the only real fix is to get rid of the cars as much as you can (after which having an extra lane can make traffic go smoother). > Both papers you cite are by the same group, and I don't think the results represent a consensus of the experts. IIRC, that kynurenine does something is apparently well-established, and not just by this group. Also, that first paper has quite a few citations, you can check for follow-up research on Google Scholar[1] [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384718/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384718/ [1] https://scholar.google.de/scholar?hl=en&as_sdt=0%2C5&q=Skeletal+Muscle+PGC-1%CE%B11+Modulates+Kynurenine+Metabolism+and+Mediates+Resilience+to+Stress-Induced+Depression&btnG= https://scholar.google.de/scholar?hl=en&as_sdt=0%2C5&q=Skele...

jessriedel 8y ago
> So that would suggest that the body just reaches a new equilibrium. This is another degree of freedom in the theory, right? I mean, this could all be true for all I know, but as an outsider I think this falls into the category of stuff I can't judge, and (like a thousand other theories investigated by experts and published in impressive places like Science) hasn't yet risen to the level of consensus.