3 ms·

"Later I learned that taurine transpoters can also transport GABA and I suspect that this might have something to do with it" Can you clarify this? Phenibut af

"Later I learned that taurine transpoters can also transport GABA and I suspect that this might have something to do with it" Can you clarify this? Phenibut affects GABA but above you said, taurine transporters can also transport GABA so I am not sure what you mean. Are you saying that Phenibut might hijack the taurine transporters so they cannot be used for Taurine? I have taken Zolpidem (which affects GABA) for sleep off and on for long periods but I am pretty sure I had this strain even when off it for 6 months or so so not super hopeful. Do I need to supplement Taurine then or is there some test for it in the retina you can have done? If it's permanent as you say that's not hopeful. However once again, and I know you said it was weirdly spcific, but since this only happens on LED backlit displays I find it hard to believe it's something like that since that should affect other visual things.

joveian 8y ago
Sorry, I didn't mean to imply that I thought permanant damage was likely in your case (unless you happened to be taking a lot of Phenibut over a long period of time), just that it is possible that some medication could somehow be causing your problem. At least GABA itself is transported by the taurine transporters and if you have enough GABA (as far as I know this has only been observed with vigabatrin use or rare genetic GABA metabolism disorders) then the retina will not get enough taurine and peripheral vision will suffer permanant damage that can only be detected with a special test until it gets quite bad. Taurine supplementation does prevent damage in that case. Phenibut might possibly have the taurine transporter issue since (unlike Zolpidem) it is considered a GABA analog plus some people take quite a lot of it and even the lowest doses are quite a bit higher than the higest Zolpidem dose. Baclofen is similar to Phenibut but used in much lower quantities so it also seems unlikely to cause that trouble (and it actually doesn't cause my eyes to hurt). And I could be completely wrong about Phenibut having that particular issue, all I really know is that it makes my eyes hurt when I use the light therapy visor. Actually, I just remembered that taurine itself causes my eyes to hurt in the same way, so while it could still potentially be taurine transporter related it at least isn't a lack of taurine for my particular issue (sorry, I am also disabled due to sleep issues in my case and either that or some additional unknown issue affects my memory). I see that Zolpidem does have multiple common eye related side effects, so somehow it can negatively affect the eyes. If you haven't been taking medication the whole time you have noticed the problem then that should be enough to conclude that it isn't medication related. Or if you are taking something else (like pain medication) but can't fairly easily change to something with a different mechanism of action then I don't think it is likely enough to be worth too much trouble (but keep the possibility in mind if you are ever in a position to test it). For me it was even more specific, just the one particular LED light that caused the trouble, not my computer screen (which is older but I just checked and it is LED backlight) or brighter natural light, or anything else. I would have also thought it should affect other visual things but somehow it didn't (although in my case maybe it is somehow connected to the LED being so close to my eyes).

joveian 8y ago

Sorry, I didn't mean to imply that I thought permanant damage was likely in your case (unless you happened to be taking a lot of Phenibut over a long period of time), just that it is possible that some medication could somehow be causing your problem. At least GABA itself is transported by the taurine transporters and if you have enough GABA (as far as I know this has only been observed with vigabatrin use or rare genetic GABA metabolism disorders) then the retina will not get enough taurine and peripheral vision will suffer permanant damage that can only be detected with a special test until it gets quite bad. Taurine supplementation does prevent damage in that case. Phenibut might possibly have the taurine transporter issue since (unlike Zolpidem) it is considered a GABA analog plus some people take quite a lot of it and even the lowest doses are quite a bit higher than the higest Zolpidem dose. Baclofen is similar to Phenibut but used in much lower quantities so it also seems unlikely to cause that trouble (and it actually doesn't cause my eyes to hurt). And I could be completely wrong about Phenibut having that particular issue, all I really know is that it makes my eyes hurt when I use the light therapy visor. Actually, I just remembered that taurine itself causes my eyes to hurt in the same way, so while it could still potentially be taurine transporter related it at least isn't a lack of taurine for my particular issue (sorry, I am also disabled due to sleep issues in my case and either that or some additional unknown issue affects my memory). I see that Zolpidem does have multiple common eye related side effects, so somehow it can negatively affect the eyes. If you haven't been taking medication the whole time you have noticed the problem then that should be enough to conclude that it isn't medication related. Or if you are taking something else (like pain medication) but can't fairly easily change to something with a different mechanism of action then I don't think it is likely enough to be worth too much trouble (but keep the possibility in mind if you are ever in a position to test it). For me it was even more specific, just the one particular LED light that caused the trouble, not my computer screen (which is older but I just checked and it is LED backlight) or brighter natural light, or anything else. I would have also thought it should affect other visual things but somehow it didn't (although in my case maybe it is somehow connected to the LED being so close to my eyes).