4 ms·
Some people have been able to successfully treat migraines, as well as cluster headaches, with hallucinogens such as psilocybin and LSD: "These patients are in
by okmokmz 8y ago
Some people have been able to successfully treat migraines, as well as cluster headaches, with hallucinogens such as psilocybin and LSD:
"These patients are in a desperate and vulnerable situation, and illicit psychoactive substances are often considered a last resort. There appeared to be little or no interest in psychoactive effects per se as these were rather tolerated or avoided by using sub-psychoactive doses. Primarily, psilocybin, lysergic acid diethylamide, and related psychedelic tryptamines were reportedly effective for both prophylactic and acute treatment of cluster headache and migraines. Treatment results with cannabis were more unpredictable. No severe adverse events were reported, but it was observed how desperation sometimes spurred risky behavior when obtaining and testing various treatment alternatives." [1]
"The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headache may be warranted."[2]
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584001/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584001/
[2] https://www.ncbi.nlm.nih.gov/pubmed/16801660 https://www.ncbi.nlm.nih.gov/pubmed/16801660
https://clinicaltrials.gov/ct2/show/NCT03341689 https://clinicaltrials.gov/ct2/show/NCT03341689
- jacob019 8y agoI have a friend who gets regular migraines. He takes triptans to abort them, but if the frequency becomes too much he takes a low dose of psilocin and it banishes them for a couple months.
- sibeliuss 8y agoI know someone who does this and the discovery has been a godsend. Doesn't even take a strong dose either!
- tpm 8y agoI know someone who uses MDMA every few months to prevent migraines. Reportedly it works at least for a month or two after a 100mg dose. Really wish it was legal to research around this compounds - the case of 2-Bromo-LSD suggests a successful anti-migraine drug does not have to have psychedelic effects.
- heyyyouu 8y agoYes, it's been found to work well on certain types of "cluster" type migranes. However, it hasn't been found to work for chronic migranes, which is what this new drug is focused on. Prevention of chronic migranes is horribly elusive, and while there's a number of "preventatives," for many people they don't work well or for very long.
- Uberphallus 8y agoI have chronic migraines, the frequency isn't too bad (2-3 times a month). Personally I've spent 2 years migraine free doing LSD and psilocybe mushrooms (and other related drugs) every couple of months during a year and a half. Sometimes in the range of microdosing: ~25µg LSD monthly for the last 3 months). I know, n=1, but still.
- heyyyouu 8y agoChronic migranes is defined as 15 days or more per month. Many people have it 24 hours a day. Frequency is what chronic migranes are about.
- okmokmz 8y agoThe study states the psylocybin was found to be effective for acute treatment of migraines. Obviously it's only one study, but unless you have sources I disagree that psychedelics have not been found to work for migraines. Also you say "'cluster' type migraines", but cluster headaches are not a sub-type of migraines.